1,326 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Introgression shapes fruit color convergence in invasive Galápagos tomato

    Matthew JS Gibson et al.
    A wild tomato species adopts local fruit color via introgression from an endemic relative, during its invasion onto the Galápagos Islands.
    1. Chromosomes and Gene Expression

    GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo

    Marissa M Gaskill et al.
    Following fertilization, the pioneering transcription factors GAGA factor (GAF) and Zelda are independently required to reprogram the zygotic genome of Drosophila and activate the first wave of gene expression.
    1. Cell Biology
    2. Neuroscience

    The synaptic ribbon is critical for sound encoding at high rates and with temporal precision

    Philippe Jean et al.
    The synaptic ribbon regulates calcium channel clustering and proper vesicle dynamics at cochlear inner hair cells to ensure precise sound encoding.
    1. Neuroscience

    The presynaptic ribbon maintains vesicle populations at the hair cell afferent fiber synapse

    Lars Becker et al.
    The auditory hair cell synaptic ribbon maintains vesicle pools near release sites in order to support sustained and timed vesicle release.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq

    Julie L Aspden et al.
    Thousands of small Open Reading Frames are translated, and form two distinct classes based on their translational efficiency and bioinformatic indicators.
    1. Biochemistry and Chemical Biology

    Efficient analysis of mammalian polysomes in cells and tissues using Ribo Mega-SEC

    Harunori Yoshikawa et al.
    Translationally active polysomes from mammalian cells/tissues are successfully separated with rapidity, high efficiency and exceptional reproducibility by a SEC-based approach, an accessible alternative to the conventional sucrose density gradient analysis.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete

    Kimberley H Gibson et al.
    The corkscrew-like motility of Spirochete bacteria is enabled by a unique, asymmetrically constructed flagellum that wraps around the cell body within the periplasm.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells

    Lavanya H Palavalli Parsons et al.
    PARP-7 is a mono(ADP-ribosyl) transferase that directs an extensive ADP-ribosylated proteome to control microtubule stability, and regulate ovarian cancer cell growth and motility.
    1. Cell Biology
    2. Developmental Biology

    Somatic clones heterozygous for recessive disease alleles of BMPR1A exhibit unexpected phenotypes in Drosophila

    Takuya Akiyama et al.
    Clonal heterozygosity for recessive disease alleles can elicit unexpected phenotypes in vivo, suggesting a new genetic concept relevant to understanding pathogenesis (deleterious heteromosaicism).
    1. Cell Biology

    The transcription factor Hey and nuclear lamins specify and maintain cell identity

    Naama Flint Brodsly et al.
    Hey together with LaminC continuously supervise nuclear organisation and differentiated enterocyte identity, a regulation that is lost upon ageing, resulting in loss of gut homeostasis.

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