7 results found
    1. Cell Biology
    2. Developmental Biology

    Coordinated genomic control of ciliogenesis and cell movement by RFX2

    Mei-I Chung, Taejoon Kwon ... John B Wallingford
    Systems-level analysis in vertebrate ciliated epithelial cells shows that the network of genes activated by the transcription factor Rfx2 controls the development, migration, insertion and function of these cells.
    1. Cell Biology

    TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella

    Hiroaki Ishikawa, Takahiro Ide ... Wallace F Marshall
    Loss of one protein from the intraflagellar transport complex leads to a defect in import of a specific sub-set of proteins into the flagellum.
    1. Cell Biology
    2. Genetics and Genomics

    Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome

    Martin Wegner, Valentina Diehl ... Manuel Kaulich
    Cloning-free 3Cs technology is developed for the generation of sequence-bias-free covalently closed circular synthesized (3Cs) CRISPR/Cas gRNA libraries that can interrogate the coding and noncoding human genome.
    1. Cell Biology

    ERK3/MAPK6 controls IL-8 production and chemotaxis

    Katarzyna Bogucka, Malvika Pompaiah ... Krishnaraj Rajalingam
    Understudied atypical MAPK, ERK3 controls epithelial secretome and chemotaxis.
    1. Cell Biology

    Modular, cascade-like transcriptional program of regeneration in Stentor

    Pranidhi Sood, Athena Lin ... Wallace F Marshall
    Regeneration of single Stentor coeruleus cells is accompanied by a program of gene expression that can be decomposed into distinct modules, showing a cascade-like organization, and involving genes with conserved function in development and cell cycle control.
    1. Structural Biology and Molecular Biophysics

    Three-dimensional flagella structures from animals’ closest unicellular relatives, the Choanoflagellates

    Justine M Pinskey, Adhya Lagisetty ... Daniela Nicastro
    Cryo-electron microscopy reveals previously undescribed structural features of choanoflagellate flagella and provides new insights into flagellar evolution.
    1. Cancer Biology
    2. Cell Biology

    ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization

    Katarzyna Bogucka-Janczi, Gregory Harms ... Krishnaraj Rajalingam
    ERK3 controls actin cytoskeleton.

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