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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity

    Nairita Maitra et al.
    Extensive molecular profiling shows how loss of highly similar, paralogous ribosomal proteins lead to distinct phenotypic outputs, through translational control of specific mRNAs.
    1. Immunology and Inflammation

    Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

    Jonathan Muri et al.
    The thioredoxin-1 (Trx1) system promotes inflammation by positively regulating both NLRP3 inflammasome responses, by detoxifying excessive ROS independently of Txnip and NF-κB binding to target DNA.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression

    Tonya Kueck et al.
    Distinct antiviral signaling pathways, triggered by the aryl hydrocarbon receptor and Interferon-gamma, converge on CDK/cyclin repression, causing inhibition of viral DNA synthesis.
    1. Cell Biology
    2. Human Biology and Medicine

    Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

    King Faisal Yambire et al.
    Impaired lysosomal acidification results in retention of iron inside lysosomes, triggering functional iron deficiency, dysfunctional mitochondria (especially mtDNA loss), and inflammation in vivo in a mouse model of lysosomal disease.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Functional and structural characterization of an ECF-type ABC transporter for vitamin B12

    Joana A Santos et al.
    ECF-CbrT is a bacterial vitamin B12 transporter that is structurally different from the well-characterized transporter BtuCDF, yet has similar functional properties.
    1. Neuroscience

    Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila

    Qingqing Liu et al.
    Gap junctions exist in Kenyon cells and Kenyon cell-mushroom body output neuron neural networks, and are also critical in visual learning and memory in Drosophila.
    1. Cancer Biology

    Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3

    Ritu Chaudhary et al.
    Functional and mechanistic analysis of p53-regulated lncRNA PINCR and its interacting RNA-binding protein Matrin 3 uncovers context-dependent regulation of specific p53 target genes during DNA damage.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural characterization of encapsulated ferritin provides insight into iron storage in bacterial nanocompartments

    Didi He et al.
    Encapsulin-associated ferritin proteins form metal-dependent decamers that are active as ferroxidase enzymes, but require encapsulation to form an iron store.
    1. Stem Cells and Regenerative Medicine

    Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria

    Carolyn E Adler et al.
    A chemical method has been developed for studying single organ regeneration and fate specification of stem cells in an adult organism.
    1. Microbiology and Infectious Disease

    Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins

    Aaron G Wexler et al.
    The human gut bacterial lipoprotein BtuG binds vitamin B12 with femtomolar affinity, can remove vitamin B12 from human intrinsic factor, and is required for commensal fitness in the gut.