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1,585 results found
    1. Developmental Biology

    Ongoing repair of migration-coupled DNA damage allows planarian adult stem cells to reach wound sites

    Sounak Sahu et al.
    Adult stem cells acquire increased DNA damage as they migrate to a wound site and require active DNA repair mechanisms for normal migration.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses

    Stephan Wilmes et al.
    IL-27 exerts differential activation of STAT1 and STAT3 via IL-27Ra and GP130, respectively, leading to a kinetic decoupling of its gene expression program, which contributes to tune its immuno-modulatory activities.
    1. Computational and Systems Biology

    A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice

    Michael A Petr et al.
    A comprehensive cross-sectional assessment reveals functional decline in mice consistent with increased energetic cost of physical activity with age through metabolic rewiring in multiple organs.
    1. Developmental Biology

    Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway

    Tra Thi Huong Dinh et al.
    Mouse genetic manipulations reveal that Cables2 is involved in the progress of gastrulation by interacting with Wnt/β-catenin and the p53 pathways in diminished Rps21 expression.
    1. Computational and Systems Biology

    Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney

    Yuka Takemon et al.
    mRNA profiling alone provides an incomplete picture of molecular aging and examination of changes in proteins is essential to understand aging processes that are not transcriptionally regulated.
    1. Microbiology and Infectious Disease

    Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

    Akshay Sabnis et al.
    Modulation of cytoplasmic lipopolysaccharide levels sensitises bacteria to polymyxin antibiotics, revealing a novel combination therapeutic approach.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3

    Francesco Beghini et al.
    The bioBakery 3 platform enables improved, integrated, and strain-level analysis of microbial communities from large-scale meta-omic data.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

    Christophe Caillat et al.
    The structure of gp41with its membrane anchors highlights the flexible linkage of the transmembrane regions and the fuson peptides, which generates an asymmetric conformation, a potential target of MPER bNAbs.
    1. Microbiology and Infectious Disease

    Lipoprotein DolP supports proper folding of BamA in the bacterial outer membrane promoting fitness upon envelope stress

    David Ranava et al.
    The envelope stress factor DolP associates with the outer membrane protein assembly machinery and supports proper folding and functioning of BamA contributing to preserve envelope integrity.
    1. Chromosomes and Gene Expression

    Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology

    Markus Terrey et al.
    Disruption of quality control pathways that function at distinct steps to mitigate errors in translation evoke similar cellular responses and pathologies.

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