Browse the search results

Page 2 of 159
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome

    Priyanka D Abeyrathne et al.
    An ensemble of cryo-EM structures reveals how eukaryotic elongation factor 2 positions the first codon of a viral mRNA for translation.
    1. Structural Biology and Molecular Biophysics

    Mechanisms of ribosome stalling by SecM at multiple elongation steps

    Jun Zhang et al.
    Nascent regulatory peptides tune the translation rate through a continuous, dynamic reshaping of the functional center of the ribosome.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling

    Ting Su et al.
    The structure of the VemP-stalled ribosome reveals a helix-double turn-helix conformation of the nascent chain within the ribosomal tunnel, illustrating how secondary structure formation directly at the peptidyltransferase center of the ribosome can induce translational arrest.
    1. Cell Biology

    Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex

    Junsheng Yang et al.
    A genome-wide screen in yeast reveals that key proteins in ribosome quality control also regulate mutant Huntingtin aggregation and toxicity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The translation elongation factor eEF1A1 couples transcription to translation during heat shock response

    Maria Vera et al.
    Eukaryotic translation elongation factor 1A1 controls the process of heat shock response, from transcriptional activation of the HSP70 gene, to HSP70 mRNA stabilization, nuclear export, and translation.
    1. Biochemistry and Chemical Biology

    Ribozyme-catalysed RNA synthesis using triplet building blocks

    James Attwater et al.
    Adopting RNA trinucleotides as substrates, ribozymes can catalyse the copying of structured RNA sequences, allowing self-synthesis by part of a newly evolved symbiotic ribozyme pair.
    1. Structural Biology and Molecular Biophysics

    The CryoEM structure of the Saccharomyces cerevisiae ribosome maturation factor Rea1

    Piotr Sosnowski et al.
    The high-resolution structure of Rea1, an essential ribosome maturation factor in Saccharomyces cerevisiae, explains how the ATPase domain is regulated and reveals the linker domain, the mechanical element carrying out ribosome remodeling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The shape of the bacterial ribosome exit tunnel affects cotranslational protein folding

    Renuka Kudva et al.
    Proteins can fold deeper inside ribosomes with an enlarged exit tunnel.
    1. Biochemistry and Chemical Biology

    Translation of 5′ leaders is pervasive in genes resistant to eIF2 repression

    Dmitry E Andreev et al.
    Most of the mRNAs whose translation is resistant to the stress-induced repression of protein synthesis contain upstream open reading frames that are efficiently translated under normal conditions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES

    Vera P Pisareva et al.
    A conformational change in the Cricket Paralysis Virus IRES upon double translocation in the ribosome uncovers an unexpected similarity with the Hepatitis C Virus IRES.