205 results found
    1. Developmental Biology

    Ripply2 recruits proteasome complex for Tbx6 degradation to define segment border during murine somitogenesis

    Wei Zhao et al.
    Inducing presomitic mesoderm (PSM)-fated ES cells clarified that Ripply2 directly interacts with Tbx6 and degrades Tbx6 in proteasome-ubiquitin pathway by recruiting the 26S proteasome, which is a PSM-specific event to define the segment border during mouse somitogenesis.
    1. Neuroscience

    Uncovering temporal structure in hippocampal output patterns

    Kourosh Maboudi et al.
    Machine learning models of coordinated hippocampal ensemble activity during sharp wave ripple activity encode structure that mirrors the place cell map expressed during exploration, and enable a new paradigm for analyzing and understanding this offline activity.
    1. Neuroscience

    Impaired spatial memory codes in a mouse model of Rett syndrome

    Sara E Kee et al.
    Hypersynchrony in a mouse model of Rett syndrome impairs ripple-dependent memory consolidation and leads to a decrease in experience-dependent refinement of place cell activities.
    1. Neuroscience

    Distinct hippocampal-cortical memory representations for experiences associated with movement versus immobility

    Jai Y Yu et al.
    During awake Sharp wave-ripple memory reactivation, hippocampal-cortical representations for movement- versus immobility-associated experiences are reactivated separately.
    1. Neuroscience

    Alterations of in vivo CA1 network activity in Dp(16)1Yey Down syndrome model mice

    Matthieu Raveau et al.
    CA1 physiology is altered in the hippocampus of Down syndrome mice during both spatial exploration and rest, paralleled by an increase in populations of interneurons responsible for single cell and network synchronization.
    1. Neuroscience

    Parvalbumin-positive interneurons mediate neocortical-hippocampal interactions that are necessary for memory consolidation

    Frances Xia et al.
    Electrophysiological and behavioural experiments reveal that parvalbumin interneuron-mediated increases in neocortical-hippocampal interactions are necessary for successful memory consolidation.
    1. Neuroscience

    Cell-specific synaptic plasticity induced by network oscillations

    Shota Zarnadze et al.
    Recordings of cellular and network activities of the mouse brain provide insights into how gamma rhythms contribute to memory formation.
    1. Cancer Biology

    Oncogene Regulation: Enhancers not required

    Ying Zheng, David Levens
    Laboratory mice with over half a megabase of DNA upstream of their Myc gene removed still thrive in the absence of stress.
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