796 results found
    1. Genetics and Genomics

    Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks

    Luca Albergante et al.
    The theory of Buffered Qualitative Stability uses the importance of biological robustness to explain many features of gene regulatory networks in a wide range of organisms, and has implications for diverse biological phenomena including the ability of bacteria and cancer cells to ‘loosen’ their robustness and hence evade treatment.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Multi-enhancer transcriptional hubs confer phenotypic robustness

    Albert Tsai et al.
    Multiple enhancers in physical proximity can reinforce shared transcriptional 'hubs' to preserve their transcriptional output, providing a buffer during environmental stresses and genetic perturbations to preserve phenotypic robustness.
    1. Developmental Biology
    2. Neuroscience

    Mutual inhibition among postmitotic neurons regulates robustness of brain wiring in Drosophila

    Marion Langen et al.
    The Notch signaling pathway has a central role in the development of the nervous system, and also in the establishment of networks of connections in the adult brain
    1. Plant Biology

    The role of APETALA1 in petal number robustness

    Marie Monniaux et al.
    Variable petal number in Cardamine hirsuta is explained by regulatory changes in the MADS-box gene APETALA1 that relaxed its epistasis over mapped QTL in the C. hirsuta genome.
    1. Computational and Systems Biology

    Meta-Research: Centralized scientific communities are less likely to generate replicable results

    Valentin Danchev et al.
    Analysis of data on drug-gene interactions suggests that decentralized collaboration will increase the robustness of scientific findings in biomedical research.
    1. Computational and Systems Biology
    2. Developmental Biology

    A repressor-decay timer for robust temporal patterning in embryonic Drosophila neuroblast lineages

    Inna Averbukh et al.
    The demand for robust performance distinguishes the mechanism which progresses the biological timer acting within neural progenitors to determine neuronal fates in the Drosophila embryo.
    1. Neuroscience

    Dopamine maintains network synchrony via direct modulation of gap junctions in the crustacean cardiac ganglion

    Brian J Lane et al.
    Dopamine is able to ensure that neural networks maintain critical features of their output, such as synchrony of neuron firing, by directly increasing coupling strength to ensure robust output is maintained.
    1. Computational and Systems Biology
    2. Developmental Biology

    Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

    Nick E Phillips et al.
    Stochasticity introduced computationally into a gene expression oscillator creates heterogeneity in the time of differentiation of identical cells and offers robustness to the progenitor state and the outcome of cell division.
    1. Cell Biology
    2. Computational and Systems Biology

    EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling

    Martin Baumdick et al.
    Plasticity arising from autocatalytic receptor activation coexists with robustness in ligand responsiveness only by differential endosomal sorting of spontaneous and ligand-activated EGFR as distinct molecular states.
    1. Neuroscience

    Synergistic plasticity of intrinsic conductance and electrical coupling restores synchrony in an intact motor network

    Brian J Lane et al.
    Neural networks like the crustacean cardiac ganglion employ multi-faceted compensatory mechanisms to achieve the stability and robustness that are critical to long-term function.

Refine your results by:

Type
Research categories