Kif26b, a new component of the evolutionarily conserved Wnt5a-Ror signaling pathway, is controlled by regulated proteolysis and plays crucial roles in mediating vertebrate embryonic tissue morphogenesis.
Signals from primate rod photoreceptors do not exhibit the light-level-dependent routing through parallel retinal circuits observed in rodents and often invoked in interpreting psychophysical experiments.
Accessible cholesterol levels in human red blood cells were found to be stable within individuals but vary >10-fold among individuals and this variability may contribute to differences in cholesterol trafficking among tissues.
The helical rod structure and dynamic spring-like properties of the type 1 pilus are evolutionarily fine-tuned for functioning in host-pathogen interactions during urinary tract infection and gut colonization.
Establishing retinal contrast transmission as a novel determinant of mammalian fitness, this research adds functional significance to a prominent exception of nuclear organization, previously described in nocturnal rod photoreceptor cells.