6,989 results found
    1. Neuroscience

    Sensory experience inversely regulates feedforward and feedback excitation-inhibition ratio in rodent visual cortex

    Nathaniel J Miska et al.
    Sensory deprivation suppresses cortical responsiveness through a selective remodeling of excitatory and inhibitory microcircuit motifs, by simultaneously amplifying feedforward and suppressing feedback excitation.
    1. Computational and Systems Biology
    2. Neuroscience

    Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit

    Marianne J Bezaire et al.
    Spontaneous theta oscillations and interneuron-specific phase preferences emerge spontaneously in a full-scale model of the isolated hippocampal CA1 subfield, corroborating and extending recent experimental findings.
    1. Human Biology and Medicine
    2. Neuroscience

    Human hippocampal CA3 damage disrupts both recent and remote episodic memories

    Thomas D Miller et al.
    Human hippocampal cornu ammonis 3 damage impairs both recent and remote autobiographical episodic memory, and disrupts functional integration in medial temporal lobe subsystem regions of the default network.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A potent human neutralizing antibody Fc-dependently reduces established HBV infections

    Dan Li et al.
    A novel and potent receptor-binding-blockage human neutralizing antibody prevents HBV infection, and suppresses HBV infection therapeutically in HBV-infected mice.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency

    Tara L Mastro et al.
    Deletion of one copy of the postsynaptic density protein synGAP in rodents causes an increase in the level of the AMPA receptor auxiliary protein TARP in PSDs only in females.
    1. Neuroscience

    Functional heterogeneity within the rodent lateral orbitofrontal cortex dissociates outcome devaluation and reversal learning deficits

    Marios C Panayi, Simon Killcross
    The rodent orbitofrontal cortex makes functionally distinct contributions to flexible behavioural control, even within a single putative orbitofrontal subregion, which has important implications for establishing homology between rodent and primate orbitofrontal cortex.
    1. Microbiology and Infectious Disease

    MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis

    Saman Hussain et al.
    MreB filaments bind, orient, and move along the direction of greatest membrane curvature, thus orienting the insertion of new glycan strands around the cell circumference in a manner that may help establish and maintain rod shape.
    1. Genetics and Genomics
    2. Plant Biology

    DNA Methylation: Epigenetics in the wild

    Adam J Bewick , Robert J Schmitz
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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome plasticity in Candida albicans is driven by long repeat sequences

    Robert T Todd et al.
    Previously uncharacterized long repeat sequences are associated with significant genome variation that can increase fitness and promote antifungal drug resistance in diverse isolates of Candida albicans.
    1. Ecology

    Sequestration and activation of plant toxins protect the western corn rootworm from enemies at multiple trophic levels

    Christelle AM Robert et al.
    The western corn rootworm escapes biological control by entomopathogenic nematodes by partitioning and phenocopying the plant defense system for self-protection.

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