807 results found
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural insights into flagellar stator–rotor interactions

    Yunjie Chang et al.
    In situ structural analysis of bacterial flagellar motor in the Lyme disease spirochete reveals novel conformational change driven by proton motive force.
    1. Microbiology and Infectious Disease

    The flagellar motor of Vibrio alginolyticus undergoes major structural remodeling during rotational switching

    Brittany L Carroll et al.
    In situ structures of the flagellar motors genetically docked in CCW and CW rotational states reveal major rearrangement that facilitates rotational switch in Vibrio alginolyticus..
    1. Cell Biology
    2. Developmental Biology

    Philosophy of Biology: The analysis of living systems can generate both knowledge and illusions

    Antony M Jose
    By thinking about experimental techniques in terms of six broad approaches – perturbation, visualization, substitution, characterization, reconstitution, and simulation – researchers may be able to generate more reliable inferences.
    1. Structural Biology and Molecular Biophysics

    Atomistic simulations indicate the c-subunit ring of the F1Fo ATP synthase is not the mitochondrial permeability transition pore

    Wenchang Zhou et al.
    The notion that the lumen of the ATP synthase membrane rotor is the long-sought megachannel that triggers the onset of the mitochondrial permeability transition is found to be inconsistent with its actual structural and functional properties.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

    Yohei Ohashi et al.
    The lipid kinase VPS34 complexes I and II are both activated by unsaturation of substrate and non-substrate lipids, curvature, electrostatics and polyphosphoinositides, which play roles in localisation and cellular function.
    1. Developmental Biology
    2. Neuroscience

    Regulation of nerve growth and patterning by cell surface protein disulphide isomerase

    Geoffrey MW Cook et al.
    The nerve growth-repellent activity that generates spinal nerve repeat-patterning in birds and mammals is identified at the molecular level, and a similar system is revealed in adult brain grey matter.
    1. Cell Biology

    Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7

    Patricia Marmol et al.
    The activin receptor ALK7 regulates the adaptation of brown adipose tissue to nutrient availability by preventing over-activation of signaling pathways induced by fasting, allowing appropriate response to cold exposure.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity

    Nairita Maitra et al.
    Extensive molecular profiling shows how loss of highly similar, paralogous ribosomal proteins lead to distinct phenotypic outputs, through translational control of specific mRNAs.
    1. Structural Biology and Molecular Biophysics

    Structural basis for ion selectivity in TMEM175 K+ channels

    Janine D Brunner et al.
    Structural and functional analysis of a recently discovered non-canonical potassium channel family reveals a unique selectivity filter that is exposed to permeating ions only in the conductive state.
    1. Neuroscience

    Visually-updated hand state estimates modulate the proprioceptive reflex independently of motor task requirements

    Sho Ito, Hiroaki Gomi
    Distortion and elimination of limb visual feedback affects low-level stretch reflex control, indicating the involvement of a high-level and multimodal representation of the limb state in orchestrating hierarchical sensorimotor control.

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