9,374 results found
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity

    Tamara M Sirey, Kenny Roberts ... Chris P Ponting
    Mitochondrial energy metabolism is post-transcriptionally regulated through an interplay between long and short non-coding RNAs.
    1. Microbiology and Infectious Disease
    2. Medicine

    A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

    Isaie J Reuling, Lisanne A van de Schans ... Teun Bousema
    Controlled human malaria infection model allows the study of gametocyte biology and dynamics providing novel insights and tools in malaria transmission and elimination efforts.
    1. Immunology and Inflammation
    2. Medicine

    Bacterial–fungal interactions in the neonatal gut influence asthma outcomes later in life

    Rozlyn CT Boutin, Charisse Petersen ... B Brett Finlay
    Overgrowth of the yeast Pichia kudriavzevii within the neonatal gut microbiota increases allergic airway disease severity later in life and may be inhibited by short-chain fatty acids.
    1. Structural Biology and Molecular Biophysics

    Structural and functional characterization of an otopetrin family proton channel

    Qingfeng Chen, Weizhong Zeng ... Youxing Jiang
    Structural and functional analysis of the OTOP3 channel from Xenopus tropicalis offers insights into the mechanism of ion transport and regulation in the otopetrin proton channel family.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The long non-coding RNA Dali is an epigenetic regulator of neural differentiation

    Vladislava Chalei, Stephen N Sansom ... Chris P Ponting
    Dali regulates transcription of the Pou3f3 locus locally and binds and regulates active promoters in trans by modulating DNA methylation status.
    1. Evolutionary Biology

    The evolution of transposable elements in Brachypodium distachyon is governed by purifying selection, while neutral and adaptive processes play a minor role

    Robert Horvath, Nikolaos Minadakis ... Anne C Roulin
    Disentangling the different selective forces shaping the evolutionary dynamics of transposable elements (TEs) in the wild grass Brachypodium distachyon.
    1. Neuroscience

    A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo

    Pierre Yger, Giulia LB Spampinato ... Olivier Marre
    A spike sorting toolbox to quickly and reliably access the activity of thousands of neurons recorded with dense extracellular probes.
    1. Neuroscience

    Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing

    Sydney M Bailes, Daniel EP Gomez ... Laura D Lewis
    The frequency content of resting-state fMRI signals contains information that can characterize and predict local variations in hemodynamic response timing which enhances the temporal precision of fMRI.
    1. Neuroscience

    Identification of a stereotypic molecular arrangement of endogenous glycine receptors at spinal cord synapses

    Stephanie A Maynard, Philippe Rostaing ... Christian G Specht
    Quantitative super-resolution correlative light and electron microscopy reveals a constant glycine receptor density at native spinal cord synapses that is maintained in the oscillator mouse model of human hyperekplexia.
    1. Neuroscience

    Disparity in temporal and spatial relationships between resting-state electrophysiological and fMRI signals

    Wenyu Tu, Samuel R Cramer, Nanyin Zhang
    There is a disparity in temporal and spatial relationships between resting-state electrophysiological and functional magnetic resonance imaging (fMRI) signals, suggesting the electrophysiological signal alone cannot fully explain the effects observed in the resting-state fMRI signal.

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