591 results found
    1. Neuroscience

    Three rules govern thalamocortical connectivity of fast-spike inhibitory interneurons in the visual cortex

    Yulia Bereshpolova et al.
    In the visual system, three rules guide the thalamocortical connectivity of cortical fast-spike interneurons and are key to understand the potent and broadly tuned feed-forward inhibition that they generate.
    1. Neuroscience

    Interneurons and oligodendrocyte progenitors form a structured synaptic network in the developing neocortex

    David Orduz et al.
    During the second postnatal week, a temporary circuit made up of specific types of neurons plus the precursors of oligodendrocytes is established in the brain, and may promote the maturation of oligodendrocytes in preparation for myelination.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila

    Shouqiang Cheng et al.
    Fly protein families Dprs and DIPs can create a multitude of complementary interfaces for homo- and heterophilic adhesion complexes, resulting in instructive roles for connectivity in the motor neuron circuitry.
    1. Neuroscience

    An afferent white matter pathway from the pulvinar to the amygdala facilitates fear recognition

    Jessica McFadyen et al.
    A subcortical white matter connection from the pulvinar to the amygdala predicts how well we recognise fearful faces and the strength of feed-forward neural connectivity.
    1. Neuroscience

    Neurexin directs partner-specific synaptic connectivity in C. elegans

    Alison Philbrook et al.
    Investigation of synapse development using a single neuron system illuminates how individual neurons specify connectivity with their postsynaptic partners and the central role of the synaptic organizer neurexin in this process.
    1. Cell Biology
    2. Neuroscience

    Astrocytes refine cortical connectivity at dendritic spines

    W Christopher Risher et al.
    Spines with multiple excitatory contacts are potential sites for competition between thalamic and cortical axons, which is regulated by the astrocytes through the secreted synaptogenic protein hevin.
    1. Neuroscience

    A transformation from temporal to ensemble coding in a model of piriform cortex

    Merav Stern et al.
    A spiking network model that examines the transformation of odor information from olfactory bulb to piriform cortex demonstrates how intrinsic cortical circuitry preserves representations of odor identity across odorant concentrations.
    1. Neuroscience

    NPAS4 recruits CCK basket cell synapses and enhances cannabinoid-sensitive inhibition in the mouse hippocampus

    Andrea L Hartzell et al.
    Behaviorally-driven expression of the immediate early gene transcription factor NPAS4 changes local circuit connectivity and short-term plasticity by selectively recruiting CCK basket cell synapses to pyramidal neuron somas.
    1. Neuroscience

    Comparisons between the ON- and OFF-edge motion pathways in the Drosophila brain

    Kazunori Shinomiya et al.
    A complete connectome of the ON and OFF motion pathways of the Drosophila optic lobe is acquired using three-dimensional EM methods, and the similarities and differences of the two pathways are uncovered.
    1. Developmental Biology
    2. Neuroscience

    Intrinsic control of neuronal diversity and synaptic specificity in a proprioceptive circuit

    Maggie M Shin et al.
    Genetic and anatomical analyses of Hox gene function uncover a limb-independent program of sensory neuron fate specification and connectivity.

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