13 results found
    1. Chromosomes and Gene Expression

    Trisomy 21 consistently activates the interferon response

    Kelly D Sullivan et al.
    Hyperactive interferon signaling is a hallmark of trisomy 21 and may contribute to many of the comorbidities associated with Down syndrome.
    1. Developmental Biology

    Targeting senescent cells enhances adipogenesis and metabolic function in old age

    Ming Xu et al.
    Senescent cells contribute to age-related fat dysfunction and can directly impair healthy fat progenitor function, in part, via the secretion of activin A.
    1. Microbiology and Infectious Disease

    Respiratory and intestinal epithelial cells exhibit differential susceptibility and innate immune responses to contemporary EV-D68 isolates

    Megan Culler Freeman et al.
    Parallel studies in primary human airway cells and stem cell-derived enteroids show that Enterovirus D-68 differentially infects and induces innate immune signaling in the respiratory and intestinal epithelium.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Hepatitis C virus exploits cyclophilin A to evade PKR

    Che C Colpitts et al.
    Hepatitis C virus evades IRF1-dependent intrinsic antiviral immunity by exploiting cyclophilin A and its regulation of PKR.
    1. Microbiology and Infectious Disease

    Single cell analysis reveals human cytomegalovirus drives latently infected cells towards an anergic-like monocyte state

    Miri Shnayder et al.
    Single-cell and bulk expression analyses reveal that HCMV latent infection drives cells towards a weaker immune-responsive state, which is important for its expression and reactivation.
    1. Cancer Biology

    FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion

    Yichao Fan et al.
    Functional and mechanistic analyses of cancer cells containing homozygous deletion of TP53 and FXR2 reveal that inhibition of FXR1 blocks cell proliferation in a collateral lethality manner, opening an avenue to develop therapies targeting such cancers.
    1. Cell Biology

    Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy

    Svasti Haricharan et al.
    The transcription factor STAT5 mediates the increased breast cancer risk associated with a late age pregnancy, but intermittent anti-STAT5 treatment can lower this risk and thus prevent breast cancer.
    1. Cell Biology

    Carcinogenesis: Targeting the link between late pregnancy and breast cancer

    Balabhadrapatruni VSK Chakravarthi, Sooryanarayana Varambally
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    1. Developmental Biology

    Erythropoietin signaling regulates heme biosynthesis

    Jacky Chung et al.
    EPO/JAK2/PKA signaling cascade via AKAP10 relocalization to the outer mitochondrial membrane results in the phosphorylation of the terminal heme synthesis enzyme ferrochelatase, which contributes to heme production in red cells.

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