The midbrain area for salience, reward and aversion in mouse brain harbours among the dopamine cells three subtypes somatostatin-expressing neurons that show combinatorial neurotransmitter phenotypes and interneuron properties.
Instant performance recovery is possible following general anesthesia-induced unconsciousness using antagonist, and the brain dynamics return abruptly to the awake state without intermediate recovery states.
A novel opioid formulation producing analgesia similar to conventional opioids without permeation of blood-brain or intestinal barriers, thus precluding sedation, constipation and respiratory depression.
Linking deep mutational scanning with engineered transcriptional reporters in human cell lines establishes a generalizable method for exploring pharmacogenomics, structure, and function across broad classes of drug receptors.
An interdisciplinary approach uncovers a new antinociceptive molecular mechanism and shows that the adhesion GPCR CIRL adjusts the sensation of gentle touch and noxious mechanical insult in opposite directions.