5 results found
    1. Medicine
    2. Immunology and Inflammation

    HIF-1α regulates IL-1β and IL-17 in sarcoidosis

    Jaya Talreja et al.
    Sarcoidosis, a granulomatous disease characterized by macrophage and T-cell activation, is found to be associated with increased HIF-1α transcriptional activity, and modulation of HIF-1α regulates inflammatory immune responses.
    1. Cancer Biology

    Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer

    Kevin M Elias et al.
    Application of machine learning to serum miRNA profiles generated through next generation sequencing identifies a biologically relevant miRNA signature which can be deployed as a qPCR test to assist the diagnosis of epithelial ovarian cancer.
    1. Genetics and Genomics

    Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

    Robert N Helsley et al.
    Loss of function of membrane-bound O-acyltransferase 7 (MBOAT7), but not transmembrane channel-like 4 (TMC4), promotes hepatic steatosis.
    1. Genetics and Genomics

    Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity

    Prithvi Raj et al.
    Genetic variations that underlie common autoimmune disease genes are predominantly regulatory and modify the expression of multiple genes within the HLA gene complex and throughout the immune system.
    1. Computational and Systems Biology

    The MR-Base platform supports systematic causal inference across the human phenome

    Gibran Hemani et al.
    Compiling public datasets into a single, centralised repository and linking directly to analytical software completely transforms the scale and scope of causal inference across the phenome.

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