Sarcoidosis, a granulomatous disease characterized by macrophage and T-cell activation, is found to be associated with increased HIF-1α transcriptional activity, and modulation of HIF-1α regulates inflammatory immune responses.

The relationship between blood groups and disease is detangled, without preconceived ideas, using population-wide data, with millions of participants and lifetime follow-up, identifying not only previously known relationships but also new insights.

A successful innate granuloma requires CCR2 to organize the macrophage ring, and without CCR2, mice succumb to Chromobacterium violaceum infection.

The function of human airway macrophages can be therapeutically manipulated by targeting cellular metabolism to support immunity in the lung, aiding the design of innovative strategies in respiratory medicine.

Studying the genomes of mammals with sparse hair covering identifies specific genes and regulatory regions responsible for the formation of hair and skin, some of which were previously unrecognized.

Application of machine learning to serum miRNA profiles generated through next generation sequencing identifies a biologically relevant miRNA signature which can be deployed as a qPCR test to assist the diagnosis of epithelial ovarian cancer.

An integrative conceptual and mathematical framework of immune variation that includes unique basal profiles associated with differential susceptibility to disease, distinct acute immune signatures associated with disease severity, and how different determinants can lead to individual pathways of illness outcome.

Loss of function of membrane-bound O-acyltransferase 7 (MBOAT7), but not transmembrane channel-like 4 (TMC4), promotes hepatic steatosis.

Genetic variations that underlie common autoimmune disease genes are predominantly regulatory and modify the expression of multiple genes within the HLA gene complex and throughout the immune system.