635 results found
    1. Neuroscience

    Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei

    Jing Ren et al.
    The combination of single-cell transcriptomics and whole-brain mapping of bulk and single-cell projections reveals the relationship between the molecular architecture, cell body distribution, and axonal arborization of serotonin neurons.
    1. Genetics and Genomics

    Science Forum: The single-cell eQTLGen consortium

    MGP van der Wijst et al.
    The single-cell eQTLGen consortium aims to pinpoint the cellular contexts in which disease-causing genetic variants affect gene expression and its regulation.
    1. Structural Biology and Molecular Biophysics

    Molecular architecture of the 90S small subunit pre-ribosome

    Qi Sun et al.
    The nearly complete architecture of the gigantic 90S precursor of small ribosomal subunit is determined by cryo-EM.
    1. Neuroscience

    NPTX2 and cognitive dysfunction in Alzheimer’s Disease

    Mei-Fang Xiao et al.
    Dysfunction of pyramidal neuron-PV interneuron circuits contributes to cognitive failure in Alzheimer's disease.
    1. Developmental Biology
    2. Genetics and Genomics

    In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse

    Marco Morselli et al.
    DNA methylation deposition is dependent on the presence of H3K4me3 and H3K36me3 histone marks.
    1. Cancer Biology

    Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

    Kashyap Dave et al.
    A tumor-specific regulatory region has been identified upstream of the Myc oncogene.
    1. Biochemistry and Chemical Biology

    LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

    Sungki Hong et al.
    LARP1 turns off and on the translation of an essential class of mRNAs by acting as a key effecter and regulator for mTORC1.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

    Jennifer Jung et al.
    An image-based multiplex autophagosome RNAi screen targeting all Rab GTPases as well as their GAPs and GEFs identifies the Rab GEF SMCR8 as multifaceted autophagy modulator, which regulates kinase activity and gene expression of ULK1.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors

    Daniel Blanco-Melo et al.
    The reconstitution of a functional envelope protein from an extinct hominid retrovirus reveals its receptor and an ancient host defense that may have led to the extinction of the virus.
    1. Developmental Biology

    SOX2 regulates acinar cell development in the salivary gland

    Elaine Emmerson et al.
    Establishment of the acinar lineage in the salivary gland requires SOX2 and parasympathetic nerves.

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