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    1. Developmental Biology
    2. Chromosomes and Gene Expression

    microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart

    Amy Heidersbach, Chris Saxby ... Deepak Srivastava
    microRNA-1 plays an essential role in the development and functioning of the heart by ensuring that genes for striated, rather than smooth, muscle are expressed there.
    1. Evolutionary Biology

    Regulated aggregative multicellularity in a close unicellular relative of metazoa

    Arnau Sebé-Pedrós, Manuel Irimia ... Iñaki Ruiz-Trillo
    The transition to the aggregative stage of Capsaspora owczarzaki, a close unicellular relative to Metazoa, is associated with significant upregulation of orthologs of genes that are important for multicellularity in metazoans.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Multiple knockout mouse models reveal lincRNAs are required for life and brain development

    Martin Sauvageau, Loyal A Goff ... John L Rinn
    Long intergenic noncoding RNA molecules (lincRNAs) are shown to have critical roles in mammalian development and physiology in vivo.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Chromatin signature of widespread monoallelic expression

    Anwesha Nag, Virginia Savova ... Alexander A Gimelbrant
    Active and repressive chromatin marks, asymmetrically distributed between alleles, distinguish gene bodies subject to epigenetically controlled monoallelic expression on autosomes in human cells.
    1. Cell Biology
    2. Developmental Biology

    Coordinated genomic control of ciliogenesis and cell movement by RFX2

    Mei-I Chung, Taejoon Kwon ... John B Wallingford
    Systems-level analysis in vertebrate ciliated epithelial cells shows that the network of genes activated by the transcription factor Rfx2 controls the development, migration, insertion and function of these cells.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

    Qin Li, Sika Zheng ... Douglas L Black
    PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.
    1. Evolutionary Biology

    Evolution of insect olfactory receptors

    Christine Missbach, Hany KM Dweck ... Ewald Grosse-Wilde
    Insect specific olfactory receptors are not an adaptation to a terrestrial insect lifestyle, but evolved later in insect evolution.
    1. Immunology and Inflammation

    Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

    Dorothy K Sojka, Beatrice Plougastel-Douglas ... Wayne M Yokoyama
    Natural killer cells that were commonly thought to circulate around the body can actually reside in distinct tissues, such as in the liver, skin or uterus, and do not re-circulate.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development

    Leonardo Gastón Guilgur, Pedro Prudêncio ... Rui Gonçalo Martinho
    The need for efficient pre-RNA splicing during early embryonic development of Drosophila indicates that the constraints imposed by the cell cycle are a force capable of driving changes in Eukaryotic gene architecture.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The translational landscape of the splicing factor SRSF1 and its role in mitosis

    Magdalena M Maslon, Sara R Heras ... Javier F Cáceres
    Identifying the translational targets of the shuttling protein, SRSF1, reveals that it is needed for normal cell division, and suggests that it couples pre-mRNA splicing and translation.