Amy Heidersbach, Chris Saxby ... Deepak Srivastava
microRNA-1 plays an essential role in the development and functioning of the heart by ensuring that genes for striated, rather than smooth, muscle are expressed there.
Arnau Sebé-Pedrós, Manuel Irimia ... Iñaki Ruiz-Trillo
The transition to the aggregative stage of Capsaspora owczarzaki, a close unicellular relative to Metazoa, is associated with significant upregulation of orthologs of genes that are important for multicellularity in metazoans.
Anwesha Nag, Virginia Savova ... Alexander A Gimelbrant
Active and repressive chromatin marks, asymmetrically distributed between alleles, distinguish gene bodies subject to epigenetically controlled monoallelic expression on autosomes in human cells.
Systems-level analysis in vertebrate ciliated epithelial cells shows that the network of genes activated by the transcription factor Rfx2 controls the development, migration, insertion and function of these cells.
PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.
Dorothy K Sojka, Beatrice Plougastel-Douglas ... Wayne M Yokoyama
Natural killer cells that were commonly thought to circulate around the body can actually reside in distinct tissues, such as in the liver, skin or uterus, and do not re-circulate.
Leonardo Gastón Guilgur, Pedro Prudêncio ... Rui Gonçalo Martinho
The need for efficient pre-RNA splicing during early embryonic development of Drosophila indicates that the constraints imposed by the cell cycle are a force capable of driving changes in Eukaryotic gene architecture.
Magdalena M Maslon, Sara R Heras ... Javier F Cáceres
Identifying the translational targets of the shuttling protein, SRSF1, reveals that it is needed for normal cell division, and suggests that it couples pre-mRNA splicing and translation.