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AAV-Txnip prolongs vision in mouse models of blindness, enhancing lactate catabolism, mitochondrial health, and ATP production in a condition that likely has a limited glucose supply.

Sarcomeres in heart muscle cells come from stress fiber-like structures that are mechanistically distinct from stress fibers in non-muscle cells.

The essential mycobacterial transcription factor RbpA interacts with promoter DNA and cooperates with another essential transcription factor, CarD, to stimulate the formation of an intermediate leading to the open promoter complex.

Deciphering the mechanism of action of a large family of natural and synthetic cytotoxic lipids bioactivated by enantiospecific oxidation into protein-reactive species inspires the development of enzyme-specific prodrugs.

A set of adaptive mutations affect only a small number of phenotypes that matter in the evolution condition, and yet contain substantial latent functional diversity revealed in distant environments.

The active zone scaffold protein RIM-BP2 performs distinct functions in vesicle release at two hippocampal synapses, providing insights on how synapses express diversity in release properties.

When exposed to high-dose ionizing radiation, tardigrades undergo extensive DNA damage, like humans, but cope by stimulating expression of DNA repair proteins and of TDR1, a novel tardigrade-specific DNA-binding protein.

Comparing the white-footed deermouse with mice and rats in an inflammation model reveals a means for the observed infection tolerance in this key animal reservoir for several human diseases.