2,337 results found
    1. Cell Biology
    2. Neuroscience

    Time- and polarity-dependent proteomic changes associated with homeostatic scaling at central synapses

    Christoph T Schanzenbächer, Julian D Langer, Erin M Schuman
    Metabolic labelling and quantitative proteomics reveal the temporal evolution of cellular and neuronal responses to global activity manipulations.
    1. Ecology
    2. Evolutionary Biology

    Tradeoffs explain scaling, sex differences, and seasonal oscillations in the remarkable weapons of snapping shrimp (Alpheus spp.)

    Jason P Dinh, SN Patek
    Observational field analyses demonstrate that within a species, variation in animal weapon size corresponds to individual differences in the costs and benefits of weaponry.
    1. Developmental Biology

    Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling in Drosophila

    Andrew Liu, Jessica O’Connell ... Richard W Carthew
    Two atypical cadherins regulate organ growth by tuning the coupling of cell cycle duration to organ size.
    1. Cell Biology
    2. Physics of Living Systems

    Stoichiometric interactions explain spindle dynamics and scaling across 100 million years of nematode evolution

    Reza Farhadifar, Che-Hang Yu ... Daniel J Needleman
    Stoichiometric interactions between microtubules and cortical force-generators set spindle size, position and dynamics, and its scaling with cell size in nematode species.
    1. Evolutionary Biology

    Isometric spiracular scaling in scarab beetles—implications for diffusive and advective oxygen transport

    Julian M Wagner, C Jaco Klok ... Jon F Harrison
    Diffusion but not advection becomes increasingly challenging for gas transport across insect spiracles as body size increases.
    1. Biochemistry and Chemical Biology

    Gene and protein expression and metabolic flux analysis reveals metabolic scaling in liver ex vivo and in vivo

    Ngozi D Akingbesote, Brooks P Leitner ... Rachel J Perry
    Transcriptomic, enzyme activity, and flux data demonstrate that metabolic scaling, the inverse correlation between body size and metabolic rate per gram of tissue, is a conserved phenomenon that occurs at multiple physiological levels and in multiple tissues.
    1. Physics of Living Systems

    Surface-to-volume scaling and aspect ratio preservation in rod-shaped bacteria

    Nikola Ojkic, Diana Serbanescu, Shiladitya Banerjee
    Rod-shaped bacteria preserve their aspect ratios and surface-to-volume scaling by maintaining a homeostatic balance between the rates of cell elongation and division protein synthesis.
    1. Cell Biology
    2. Neuroscience

    A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling

    Chi-Hong Wu, Vedakumar Tatavarty ... Gina G Turrigiano
    Activity-dependent bidirectional changes in phosphorylation of the autism-associated scaffold protein Shank3 are essential for the expression of homeostatic synaptic plasticity.
    1. Evolutionary Biology

    Evidence for adolescent length growth spurts in bonobos and other primates highlights the importance of scaling laws

    Andreas Berghaenel, Jeroen MG Stevens ... Verena Behringer
    Scaling laws reveal the presence of adolescent growth spurts in bonobos and potentially in other non-human primates, challenging the notion of these spurts as a uniquely human trait and emphasizing the need to consider scaling laws when interpreting growth patterns.
    1. Developmental Biology

    Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

    Marketa Kaucka, Tomas Zikmund ... Igor Adameyko
    The clonal oriented cell dynamics enables directional expansion and accurate scaling of sheet-like or rod-like cartilaginous elements and uncouples the mechanisms of elongation from thickness or diameter control.

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