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    1. Developmental Biology
    2. Neuroscience

    Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cell number and organ growth

    Ryan T Willett, N Sumru Bayin ... Alexandra L Joyner
    The first born excitatory cerebellar nuclei neurons influence the survival of their Purkinje cell partners which stimulate the expansion of granule cells and interneurons to produce functional local circuits.
    1. Neuroscience

    Synaptic up-scaling preserves motor circuit output after chronic, natural inactivity

    Joseph M Santin, Mauricio Vallejo, Lynn K Hartzler
    Synaptic scaling maintains motor output from the respiratory network of bullfrogs after months of inactivity in the winter, providing evidence for homeostatic plasticity in response to large ecologically relevant perturbations in neuronal activity.
    1. Evolutionary Biology

    Novel neuroanatomical integration and scaling define avian brain shape evolution and development

    Akinobu Watanabe, Amy M Balanoff ... Mark A Norell
    More integrated brains in crown birds evolved through a mosaic assembly of new evolutionary and developmental dynamics across neuroanatomical regions that occurred along the dinosaur-bird transition.
    1. Developmental Biology
    2. Neuroscience

    Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas

    Andreas Zembrzycki, Adam M Stocker ... Dennis DM O'Leary
    Primary and higher order visual area dimensions in the neocortex are determined by the same genetic mechanisms during development which in turn also control the proportionate scaling between them.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Enhancing TCR specificity predictions by combined pan- and peptide-specific training, loss-scaling, and sequence similarity integration

    Mathias Fynbo Jensen, Morten Nielsen
    NetTCR 2.2 demonstrates advances in predicting MHC-peptide-TCR interactions through integration of pan- and peptide-specific training strategies, loss-scaling and sequence similarity scoring.
    1. Cell Biology
    2. Developmental Biology

    Mitotic spindle scaling during Xenopus development by kif2a and importin α

    Jeremy D Wilbur, Rebecca Heald
    An interaction between two proteins enables the spindle—the structure that segregates chromosome pairs during mitosis—to change size as cells divide.
    1. Physics of Living Systems

    Body size-dependent energy storage causes Kleiber’s law scaling of the metabolic rate in planarians

    Albert Thommen, Steffen Werner ... Jochen C Rink
    A combination of experimental and theoretical analysis identifies body size-dependent energy storage as the physiological cause of 3/4-power law scaling of the metabolic rate in planarians.
    1. Physics of Living Systems

    Local volume concentration, packing domains, and scaling properties of chromatin

    Marcelo A Carignano, Martin Kroeger ... Igal Szleifer
    The Self Returning Excluded Volume model is the first heuristic, stochastic chromatin model that reproduce single cell and ensemble based experiments bridging nucleosome and chromosome scales.
    1. Neuroscience

    GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation

    Carlos Gonzalez-Islas, Zahraa Sabra ... Peter Wenner
    Chronic perturbations of spiking activity trigger compensatory changes in GABAergic synaptic strength, but not compensatory changes in AMPAergic synaptic strength.
    1. Cell Biology
    2. Physics of Living Systems

    Physical basis of the cell size scaling laws

    Romain Rollin, Jean-François Joanny, Pierre Sens
    A theoretical model explains how protein density and nuclear to cell volume ratio are maintained during cell growth, discusses conditions under which this breaks down, and highlights the importance of metabolites, mainly amino acids such as glutamate, in this homeostasis.