284 results found
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development

    Julien G Roth et al.
    A model of in vitro human corticogenesis identifies alterations in gene expression caused by loss of 16p11.2 CNV genes in hiPSC-derived progenitor cells.
    1. Neuroscience

    The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment

    Shaun S Sanders et al.
    ZDHHC14 controls palmitoylation and axon initial segment targeting of PSD93 and Kv1-family potassium channels, events that are essential for normal neuronal excitability.
    1. Neuroscience

    Maternal cortisol is associated with neonatal amygdala microstructure and connectivity in a sexually dimorphic manner

    David Q Stoye et al.
    Prenatal stress is transmitted to infant development through cortisol, which imparts sex-specific effects on the development and connectivity of the amygdalae.
    1. Neuroscience

    Altered hippocampal-prefrontal communication during anxiety-related avoidance in mice deficient for the autism-associated gene Pogz

    Margaret M Cunniff et al.
    In POGZ heterozygous mice, reduced anxiety-related avoidance is associated with decreased feedforward inhibition and theta synchrony in the hippocampal-prefrontal pathway.
    1. Neuroscience

    The amygdala instructs insular feedback for affective learning

    Dominic Kargl et al.
    Hierarchical information flow in a cortico-limbic loop between the insular cortex, central amygdala and the cholinergic basal forebrain links bodily states with environmental stimuli to guide fear and reward behavior.
    1. Chromosomes and Gene Expression

    Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model

    Jade Hebras et al.
    Knockout of Snord115 has mild impact on expression and function of the serotonin 2C receptor.
    1. Neuroscience

    Gamma activity accelerates during prefrontal development

    Sebastian H Bitzenhofer et al.
    Maturation of inhibitory feedback accelerates gamma activity in the medial prefrontal cortex during development.
    1. Neuroscience

    Convergence of cortical types and functional motifs in the human mesiotemporal lobe

    Casey Paquola et al.
    A novel model of the human mesiotemporal lobe suggests that its broad roles in cognition can be explained by how its cytoarchitecture and form relate to large-scale functional motifs.
    1. Cell Biology

    Antipsychotic olanzapine-induced misfolding of proinsulin in the endoplasmic reticulum accounts for atypical development of diabetes

    Satoshi Ninagawa et al.
    The mechanism identified here that mediates olanzapine-induced b-cell dysfunction should be considered, along with weight gain, in mitigating adverse side effects when patients with schizophrenia are prescribed olanzapine.
  1. Episode 70: November 2020

    In this episode, we hear about artificial intelligence and in vitro fertilization, scar-free wound healing, decision-making, mosquitoes and open-access publishing.

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