186 results found
    1. Computational and Systems Biology

    Cell-cycle-gated feedback control mediates desensitization to interferon stimulation

    Anusorn Mudla et al.
    Cell cycle gating enables a temporal compartmentalization of negative vs positive feedback control processes, leading to differential responses to repetitive interferon stimulations.
    1. Cancer Biology
    2. Cell Biology

    MAPK activity dynamics regulate non-cell autonomous effects of oncogene expression

    Timothy J Aikin et al.
    The temporal patterns of MAPK activity differentially regulate cell autonomous and non-cell autonomous effects of oncogene expression.
    1. Neuroscience

    An essential role for MEF2C in the cortical response to loss of sleep in mice

    Theresa E Bjorness et al.
    The transcription factor, MEF2C, mediates a change in approximately one half of the expressed frontal cortical transcriptome controlling cellular metabolism and synaptic strength in response to acute loss of sleep.
  1. Ben Barres Spotlight Awards: Applications open for 2020

    Applications are now open for this year’s Ben Barres Spotlight Awards, offering scientists from groups that are underrepresented in science up to $6,000 each to use to advance their research career.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment

    Xiaoshan Shi et al.
    Hydrogen-deuterium exchange, electron microscopy, and vesicle reconstitution show how binding of the autophagy adaptor NDP52 to the FIP200 subunit of the ULK1 complex triggers membrane binding in autophagy.
    1. Developmental Biology
    2. Genetics and Genomics

    An atlas of cell types in the mouse epididymis and vas deferens

    Vera D Rinaldi et al.
    A systematic survey of the epididymis identifies the cell types involved in post-testicular maturation of sperm.
  2. Research Culture: Changing how we evaluate research is difficult, but not impossible

    Anna Hatch, Stephen Curry
    The DORA initiative offers practical guidance on improving the assessment of research by universities, research institutions, and funders.
  3. electrophysiological signals

    Python for the practicing neuroscientist: an online educational resource

    Learn to analyze neural data using Python with this interactive, case study-based approach
  4. Research Culture: Actionable recommendations from trainees to improve science training

    Stephanie M Davis et al.
    Early-career researchers propose seven actions that can be taken by research institutions and departments to improve science training.
    1. Neuroscience

    Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat

    Lisa R Beutler et al.
    Neurons that promote hunger become desensitized to dietary fat in obesity.

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