147 results found
    1. Developmental Biology
    2. Neuroscience

    Pum2 and TDP-43 refine area-specific cytoarchitecture post-mitotically and modulate translation of Sox5, Bcl11b, and Rorb mRNAs in developing mouse neocortex

    Kawssar Harb, Melanie Richter ... Kent Duncan
    RNA-binding proteins use both translational activation and repression of key molecular determinants to post-mitotically sculpt the identity and connectivity of developing mouse neocortex in an area-specific manner.
    1. Ecology
    2. Evolutionary Biology

    Fin whale song evolution in the North Atlantic

    Miriam Romagosa, Sharon Nieukirk ... Mónica A Silva
    The rapid and gradual fin whale songs changes adopted by individuals of a certain area provide evidence of vocal learning in this species, elucidate patterns of song evolution and hints on the limits of song variation.
    1. Developmental Biology
    2. Neuroscience

    GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation

    Meghan Morgan-Smith, Yaohong Wu ... William D Snider
    The kinase GSK-3 regulates cortical neuronal migration and dendritic orientation by phosphorylating key cytoskeletal proteins.
    1. Stem Cells and Regenerative Medicine

    Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

    John P Russell, Xinhong Lim ... Cynthia L Andoniadou
    Stem cells of the pituitary gland contribute to organ growth cell non-autonomously by promoting proliferation of committed progenitors through WNT ligand secretion.
    1. Physics of Living Systems

    Gendered hiring and attrition on the path to parity for academic faculty

    Nicholas LaBerge, Kenneth Hunter Wapman ... Daniel B Larremore
    Achieving gender parity among U.S. tenured and tenure-track faculty will require changes to hiring, which has substantially greater impacts on faculty gender representation than gendered differences in attrition rates.
    1. Developmental Biology
    2. Neuroscience

    A Notch-dependent transcriptional mechanism controls expression of temporal patterning factors in Drosophila medulla

    Alokananda Ray, Xin Li
    Cell-cycle-dependent Notch signaling cooperates with temporal transcription factors to promote the progression of the temporal transcription factor cascade in Drosophila medulla neuroblasts.
    1. Neuroscience

    A complex peripheral code for salt taste in Drosophila

    Alexandria H Jaeger, Molly Stanley ... Michael D Gordon
    Unlike other taste modalities, the Drosophila taste system encodes salt taste combinatorially across multiple sensory neuron classes, which combine to produce behavioural valence and plasticity.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Complex aneuploidy triggers autophagy and p53-mediated apoptosis and impairs the second lineage segregation in human preimplantation embryos

    Marius Regin, Yingnan Lei ... Claudia Spits
    Aneuploid human embryonic cells are eliminated by p53-mediated apoptosis in a gene dosage dependent manner.
    1. Developmental Biology
    2. Neuroscience

    Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures

    Yanshu Wang, Mark F Sabbagh ... Jeremy Nathans
    Elevating beta-catenin signaling converts endothelial cells in typically fenestrated central nervous system vasculature to a blood-brain barrier (BBB) phenotype and promotes a BBB gene expression program and chromatin landscape.
    1. Computational and Systems Biology
    2. Medicine

    Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury

    Abel Torres-Espín, Jenny Haefeli ... The TRACK-SCI Investigators
    The application of topological network analysis on multicenter high-frequency intra-operative physiology data discovers a precise range of blood pressure during surgery predicting poor recovery in spinal cord injury patients.

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