3,011 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    COVID-19 cluster size and transmission rates in schools from crowdsourced case reports

    Paul Tupper, Shraddha Pai ... Caroline Colijn
    Fitting a simple model of COVID-19 transmission to crowdsourced case report data allowed the estimation of mean cluster size and transmission rates in Canadian schools, as well as determining which interventions are most likely to limit transmission.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism

    Ute I Scholl, Gabriel Stölting ... Richard P Lifton
    A novel Mendelian disease featuring early-onset hypertension is caused by a recurrent gain of function mutation in CACNA1H, which encodes the voltage-gated calcium channel Cav3.2.
    1. Computational and Systems Biology
    2. Neuroscience

    Automatically tracking feeding behavior in populations of foraging C. elegans

    Elsa Bonnard, Jun Liu ... Monika Scholz
    A new tool enables measuring feeding and locomotion simultaneously which will enable insights into environmental, developmental, neuronal, and genetic factors underlying behavioral regulation.
    1. Neuroscience

    Postsynaptic mitochondria are positioned to support functional diversity of dendritic spines

    Connon I Thomas, Melissa A Ryan ... Benjamin Scholl
    Correlated light and electron microscopy of cortical neurons reveals a local organization of mitochondria near dendritic spines with diverse functional properties.
    1. Neuroscience

    Excitation and inhibition in anterior cingulate predict use of past experiences

    Jacqueline Scholl, Nils Kolling ... Matthew FS Rushworth
    Neurotransmitter balance in a region in frontal cortex controls how much people use information they have learnt to guide their behaviour.
    1. Neuroscience

    Catecholaminergic modulation of meta-learning

    Jennifer L Cook, Jennifer C Swart ... Roshan Cools
    A human psychopharmacology study reveals that a drug that affects the dopamine and noradrenaline systems enhances people's ability to adapt their learning rate to suit the volatility of the environment.
    1. Neuroscience

    Evidence for absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity

    Ruben van den Bosch, Frank H Hezemans ... Roshan Cools
    The absence of generally assumed strong correlations between striatal dopamine synthesis capacity and simple indices of working memory capacity, trait impulsivity, and spontaneous eye-blink rate warrants caution for using these traits as proxy measures to replace direct striatal dopamine assessments.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Controlling SARS-CoV-2 in schools using repetitive testing strategies

    Andrea Torneri, Lander Willem ... Pieter JK Libin
    In primary schools, where vaccination coverage can be low, a repetitive testing strategy reduces SARS-CoV-2 infections while keeping classes and schools open, as such limiting infection transmissions and absenteeism.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation

    Morgane Boone, Lan Wang ... Michael Schoof
    Genetically induced conformational modulation of eIF2B activates the Integrated Stress Response by impairing nucleotide exchange.
    1. Chromosomes and Gene Expression

    Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome

    Heon Shin, Amy Leung ... Dustin E Schones
    Extracellular glucose promotes O-GlcNAcylation of DNMT1 and inhibition of DNMT1 function in the maintenance of genomic methylation.

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