438 results found
    1. Neuroscience

    Movement-related coupling of human subthalamic nucleus spikes to cortical gamma

    Petra Fischer et al.
    When coupling between STN spikes and cortical gamma oscillations was strong, subsequent movement was initiated earlier, independent of changes in mean firing rates, demonstrating the importance of relative spike timing.
    1. Computational and Systems Biology
    2. Neuroscience

    A model for focal seizure onset, propagation, evolution, and progression

    Jyun-you Liou et al.
    Usage-dependent inhibition breakdown and neural adaptation underpins the key spatiotemporal dynamics of human focal seizures.
    1. Neuroscience

    Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy

    Wu Chen et al.
    Two genetically distinct Stxbp1 haploinsufficiency mouse models exhibit seizures and impairments in cognitive, psychiatric, and motor functions, representing robust preclinical models of STXBP1 encephalopathy with both construct and face validity.
    1. Neuroscience

    Proteome profile of peripheral myelin in healthy mice and in a neuropathy model

    Sophie B Siems et al.
    A comprehensive compendium of myelin proteins in the peripheral nervous system has been created, alongside a method to address molecular diversity of myelin sheaths in health and disease.
    1. Evolutionary Biology

    The evolution of the vestibular apparatus in apes and humans

    Alessandro Urciuoli et al.
    The morphology of the inner ear distinguishes major anthropoid clades and enables the proposal of various shared-derived features for apes as a whole, lesser apes, and great apes and humans.
    1. Developmental Biology
    2. Plant Biology

    Genetic analysis of the Arabidopsis TIR1/AFB auxin receptors reveals both overlapping and specialized functions

    Michael J Prigge et al.
    Genetic analyses reveal that the TIR1/AFB auxin receptors have broadly overlapping functions throughout plant development, but that the AFB1 receptor has a specialized role in a rapid auxin response.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress

    Mable Lam et al.
    Death receptor 5 can directly sense misfolded proteins downstream of the endoplasmic reticulum to provide a quality control mechanism that executes apoptosis and prevents further production of misfolded proteins.
    1. Cell Biology

    Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes

    Natalia Wesolowska et al.
    Combined light and electron microscopy reveals a new function for Arp2/3-mediated actin assembly in nuclear envelope rupture, which leads to a separation of nuclear membranes and pores from the lamina.
    1. Cell Biology

    Kinesin Kif2C in regulation of DNA double strand break dynamics and repair

    Songli Zhu et al.
    Kinesin Kif2C is recruited to DNA damage sites, modulates the mobility and dynamics of DNA damage foci, and promotes DNA double strand break repair.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications

    Sebastià Franch-Expósito et al.
    CNApp is a novel and unique web-based software that enables the performance of comprehensive and integrative analysis of genomic copy number alterations to uncover new associations with patient-oriented relevance.

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