Using genetics, it is possible to uncouple higher adiposity from its adverse metabolic effects and show that some obesity-associated conditions may benefit from treating the metabolic effects alone, whilst others may benefit more from weight loss.

Mediator, a transcriptional coactivator complex, is essential for transcription but is not a required component of a functional preinitiation complex, indicating that Mediator is not equivalent to a general transcription factor.

Height in early adulthood is an indicator that integrates across different dimensions of sustainable human development with links to health and longevity, nutrition, education and economic productivity.

High variability in neuropathology burden and interactions between dementia diagnosis and RNA quality present underappreciated complications when studying dementia in an aged population.

The gene Odd-paired is a late-acting regulator of zygotic gene expression, functioning coordinately with Zelda to influence chromatin accessibility and affecting genes expressed along both axes of Drosophila embryos.

The transcription networks controlling biofilm formation in Candida species exhibit 'structural' similarities, but show gradual substitutions of transcription regulators and frequent changes in target genes.

Mesencephalic origin of the zebrafish thalamocortical-like visual projection neurons indicates independent evolution of tectofugal visual pathways in amniotes and teleosts.

During Kupffer's vesicle morphogenesis, cell volume anisotropy impacts cell shape changes.

In an unusual complex that is not dissociated by RanGTP alone, Importin-9 sequesters the H2A-H2B core from promiscuous interactions.

People use vmPFC-dependent forward thinking to guide social choices and exploit the controllability of social environments, expanding the role of this neurocomputational mechanism beyond spatial and cognitive mapping.