561 results found
    1. Structural Biology and Molecular Biophysics

    Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

    Fenghui Zhao et al.
    The structure provides key insights into hormone recognition and activation of the glucose-dependent insulinotropic polypeptide receptor.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Research: Evolutionary medicine

    George H Perry
    In recognition that evolutionary theory is critical for understanding modern human health, eLife is publishing a special issue on evolutionary medicine to showcase recent research in this growing and increasingly interdisciplinary field.
    Editorial
    Available as:
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    1. Immunology and Inflammation

    Pioneer neutrophils release chromatin within in vivo swarms

    Hannah M Isles et al.
    Neutrophil swarms form around a single endogenous pioneer neutrophil in vivo, mediated by DNA release from pioneer neutrophils.
    1. Cell Biology
    2. Neuroscience

    Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development

    Maryam Izadi et al.
    Extended biochemical and functional analyses in primary neurons show that early neuronal morphogenesis critically relies on cooperation of the actin nucleator Cobl and its ancestor Cobl-like and uncover their cooperative mechanisms at dendritic branch initiation sites.
  1. eLife Latest: Our new Ethics Committee

    A new eLife Ethics Committee will advise and develop policy focused on establishing and maintaining the highest standards of research and publication practices across the scope of the journal.
    1. Immunology and Inflammation
    2. Medicine

    Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2

    Dongjin Jeong et al.
    Soluble Fas ligand interacts specifically with tumor necrosis factor receptor superfamily (TNFRSF)10B, also known as death receptor 5, exacerbating arthritis in a Fas-independent manner.
  2. Preprints and peer review at eLife

    We remind researchers that we now only peer review articles posted by the authors on a preprint server.
  3. What we have learned about preprints

    We discuss feedback from the community as eLife moves to only reviewing preprints.
    1. Medicine

    Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

    Cheng-Chia Tang et al.
    Simultaneous inhibition of two distinct kinase targets stimulates bone formation without concurrently increasing bone resorption, therefore representing a promising new treatment strategy for osteoporosis.
  4. Hands gesturing in front of a laptop with woman in the backgroun

    eLife Innovation Sprint 2021: Applications are now open

    We welcome applicants that want to make an impact on our selection of projects at our Sprint 2021 event.

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