21 results found
  1. Scientific Publishing: Beyond scoops to best practices

    Eve Marder
    Authors submitting a manuscript to eLife are encouraged to upload it to a recognized preprint server at the same time in order to make their results available as quickly and as widely as possible.
    Editorial
    Available as:
    • HTML
    • PDF
  2. Point of View: How open science helps researchers succeed

    Erin C McKiernan et al.
    Open research practices bring significant benefits to researchers.
    1. Epidemiology and Global Health

    Effects of water, sanitation, handwashing, and nutritional interventions on telomere length among children in a cluster-randomized controlled trial in rural Bangladesh

    Audrie Lin et al.
    In a randomized controlled trial in rural Bangladesh, an intensive, combined water, sanitation, handwashing, and nutrition intervention delivered to compounds of newborn children increased telomere length attrition during their first year of life.
    1. Neuroscience

    Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons

    Silvia Ripamonti et al.
    Perturbation of oxytocin signaling causes alterations that may be causally involved in the etiology of oxytocin-related neurobehavioral disorders.
    1. Human Biology and Medicine

    Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist

    Nicolas Damond et al.
    Contrary to previous reports, a complete absence of glucagon signaling is not sufficient to prevent diabetes after near-total β-cell loss.
    1. Neuroscience

    Modulation of anxiety and fear via distinct intrahippocampal circuits

    Elif Engin et al.
    The hippocampus features a double dissociation in its circuits with respect to the regulation of fear and anxiety, with CA3 and the dentate gyrus implicated in anxiety and CA1 in fear.
    1. Biochemistry
    2. Biophysics and Structural Biology

    A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

    Sunbin Liu et al.
    Structural and functional analyses show how the spliceosomal Prp3 protein concomitantly binds double- and single- stranded regions in U4/U6 di-snRNAs and serves to stabilize the U4/U6•U5 tri-snRNP for splicing.
    1. Genomics and Evolutionary Biology

    Admixture into and within sub-Saharan Africa

    George BJ Busby et al.
    Gene flow analysis reveals that the genomes of most sub-Saharan populations are the result of recent historical admixture events.
    1. Biophysics and Structural Biology
    2. Computational and Systems Biology

    Precise assembly of complex beta sheet topologies from de novo designed building blocks

    Indigo Chris King et al.
    Protein structures with complex topologies can be designed by recombining small independently folded domains.
    1. Neuroscience

    EM connectomics reveals axonal target variation in a sequence-generating network

    Jörgen Kornfeld et al.
    Combining light microscopy and electron microscopy uncovered patterns of neural connectivity in a zebra finch forebrain region capable of generating song-related sequential activity, contributing to our understanding of the neural circuitry that underlies skilled motor performance.

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