160 results found
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F

    Carolina Alvadia et al.
    While activated by a common mechanism, both functions in TMEM16F - lipid scrambling and ion conduction - are likely mediated by alternate protein conformations that are at equilibrium in the ligand-bound state.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM

    Valeria Kalienkova et al.
    cryo-EM reveals the properties of distinct conformations occupied during activation of the lipid scramblase nhTMEM16 and provides new insights into its interactions with the lipid environment.
    1. Structural Biology and Molecular Biophysics

    Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase

    Maria E Falzone et al.
    Structures of a TMEM16 phospholipid scramblase reveal that its Ca2+-dependent activation entails global conformational changes and how these rearrangements affect the membrane to enable transbilayer lipid transfer.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Identification of a lipid scrambling domain in ANO6/TMEM16F

    Kuai Yu et al.
    The amino acids that are necessary for phospholipid scrambling by ANO6/TMEM16F can, via domain swapping, confer scrambling activity to the chloride ion channel ANO1 that normally does not scramble phospholipids.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase

    Tao Jiang et al.
    A concerted approach employing equilibrium and biased molecular simulations, electrophysiology, mutagenesis, and functional assays reveals, in atomic details, the mechanism and pathway for transport of phospholipids and ions by a lipid scramblase.
    1. Structural Biology and Molecular Biophysics

    Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins

    Angela Ballesteros et al.
    The structural relationship between TMC and TMEM16 proteins provides insight into the structure and functional mechanisms of the mechanotransduction channel complex in hair cells.
    1. Structural Biology and Molecular Biophysics

    Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A

    Cristina Paulino et al.
    Single-particle cryo-EM and electrophysiology studies of the chloride channel TMEM16A reveals the structural basis for anion conduction and uncover its relationship to lipid scramblases of the same family.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity

    Wenlei Ye et al.
    TMEM16F shifts its ion selectivity in response to change of intracellular Ca2+, membrane potential and ionic strength.
    1. Developmental Biology

    Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition

    Yun Huang et al.
    Soon after fertilisation, a critical portion of the embryonic genome is switched on through the actions of maternally inherited Stella, in part through controlling the activation of transposable elements.

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