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    1. Neuroscience

    Decoding the Cognitive map: Learning place cells and remapping

    Markus Borud Pettersen, Vemund Sigmundson Schøyen ... Mikkel Elle Lepperød
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Computational and Systems Biology
    2. Neuroscience

    Front-end Weber-Fechner gain control enhances the fidelity of combinatorial odor coding

    Nirag Kadakia, Thierry Emonet
    In multi-channel sensory systems, gain adaptation can help maintain not only coding capacity across changes in signal intensity, but also combinatorial representations of odor identity.
    1. Immunology and Inflammation

    Aurora kinase A promotes trained immunity via regulation of endogenous S-adenosylmethionine metabolism

    Mengyun Li, Huan Jin ... Xiaojun Xia
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Foveated metamers of the early visual system

    William F. Broderick, Gizem Rufo ... Eero P. Simoncelli
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Neuroscience

    Barcode activity in a recurrent network model of the hippocampus enables efficient memory binding

    Ching Fang, Jack Lindsey ... Selmaan Chettih
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation

    Formin-like 1β phosphorylation at S1086 is necessary for secretory polarized traffic of exosomes at the immune synapse in Jurkat T lymphocytes

    Javier Ruiz-Navarro, Sara Fernández-Hermira ... Manuel Izquierdo Pastor
    FMNL1β is phosphorylated on S1086 in a protein kinase C δ (PKCδ)-dependent manner and S1086-phosphorylated FMNL1β acts downstream of PKCδ to regulate centrosome and multivesicular bodies polarization to the immunological synapse and exosome release.
    1. Cancer Biology

    Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

    James Boot, Gabriel Rosser ... Silvia Marino
    A proportion of glioblastoma with global hypo-methylation are enriched for an astrocytic signature and display increased invasion and altered immune landscape.
    1. Cell Biology

    Mapping the dynamics of force transduction at cell–cell junctions of epithelial clusters

    Mei Rosa Ng, Achim Besser ... Gaudenz Danuser
    The integrated quantification of spontaneous dynamic cell-cell force transmissions at both multi-cellular and subcellular scales enables spatiotemporal correlations of stress distribution with biomolecules in small cell clusters.
    1. Developmental Biology

    Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination

    Ruonan Zhao, Emma L Moore ... Paul A Trainor
    Epithelial to mesenchymal transition (EMT) is a continuous process, in which the transition or intermediate states can be molecularly and spatially defined, shedding new light on development and disease EMT.
    1. Neuroscience

    MicroRNA-218 instructs proper assembly of hippocampal networks

    Seth R Taylor, Mariko Kobayashi ... Giordano Lippi
    MicroRNA-218 is required in both excitatory and inhibitory neurons of the developing hippocampus to regulate intrinsic and network excitability.