6,259 results found
    1. Genetics and Genomics

    Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling

    Andres M Lebensohn et al.
    A systematic genetic analysis comprising seven genome-wide screens in haploid human cells uncovered new regulatory mechanisms at most levels in the WNT signaling pathway.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls

    Lucas D Sanor et al.
    A novel CRISPR-based genetic screen of candidate regeneration genes in haploid axolotl limbs reveals two genes required for proper regeneration.
    1. Developmental Biology
    2. Human Biology and Medicine

    Functional genome-wide siRNA screen identifies KIAA0586 as mutated in Joubert syndrome

    Susanne Roosing et al.
    A supervised learning approach on a high-content genome-wide siRNA screen has identified 591 likely candidates for ciliopathies and facilitated in the discovery of KIAA0586 mutations in individuals with Joubert syndrome.
    1. Developmental Biology

    An RNAi screen unravels the complexities of Rho GTPase networks in skin morphogenesis

    Melanie Laurin et al.
    An unprecedented large-scale screen in mice for morphogenetic regulators of tissue development provides major new insights into the roles of Rho GTPases in diverse array of skin developmental processes.
    1. Neuroscience

    Psychophysics: Time is of the essence for auditory scene analysis

    Andrew R Dykstra, Alexander Gutschalk
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    1. Microbiology and Infectious Disease

    A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV

    Molly OhAinle et al.
    Host restriction factors that block cross-species transmission also play a role in limiting the replication of highly-adapted HIV-1 in IFN-stimulated cells.
    1. Cell Biology
    2. Human Biology and Medicine

    A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

    Miyuki Suzawa et al.
    The FDA-approved compound and plant extract tannic acid is a non-toxic chemical tool for modulating sumoylation in multiple platforms.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Pyphe, a python toolbox for assessing microbial growth and cell viability in high-throughput colony screens

    Stephan Kamrad et al.
    An open-source python package for phenotype analyses provides a versatile, modular and user-friendly solution to determine complementary fitness-related traits from large-scale assays of microbial colonies.
    1. Neuroscience

    Image content is more important than Bouma’s Law for scene metamers

    Thomas SA Wallis et al.
    Peripheral appearance models emphasising pooling processes that depend on retinal eccentricity will instead need to explore input-dependent grouping and segmentation.
    1. Neuroscience

    Functional double dissociation within the entorhinal cortex for visual scene-dependent choice behavior

    Seung-Woo Yoo, Inah Lee
    The medial and lateral subdivisions of the entorhinal cortex are important for deciding "where to go from here" and "what to do to this object" in a visual context, respectively.

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