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    1. Computational and Systems Biology
    2. Neuroscience

    A synergistic workspace for human consciousness revealed by Integrated Information Decomposition

    Andrea I Luppi, Pedro AM Mediano ... Emmanuel A Stamatakis
    Anaesthesia and disorders of consciousness both reduce the capacity of the human brain to integrate information, specifically targeting interactions within a shared circuit of regions in the brain’s default network.
    1. Neuroscience

    A fear conditioned cue orchestrates a suite of behaviors in rats

    Amanda Chu, Nicholas T Gordon ... Michael A McDannald
    Comprehensive behavioral ethograms reveal a fear conditioned cue to elicit a temporally organized suite of behaviors spanning freezing, locomotion, rearing, and jumping.
    1. Neuroscience

    Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer’s disease

    Elissavet Chartampila, Karim S Elayouby ... Helen E Scharfman
    Supplementing the diet in early life with choline improved memory, neuronal morphology, and neuronal activity in mice with a genetic form of Alzheimer's disease, whereas low choline had mixed effects.
    1. Neuroscience

    Rule-based modulation of a sensorimotor transformation across cortical areas

    Yi-Ting Chang, Eric A Finkel ... Daniel H O'Connor
    Preparatory states within the motor cortex play a critical role in selecting an appropriate action in response to sensory input, dependent on the context.
    1. Cell Biology

    Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice

    Ang Li, Jianxun Yi ... Jingsong Zhou
    The distinct transcriptomic features of extraocular muscle satellite cells, partially mimicked by NaBu treatment, endow enhanced self-renewal and axon attraction, contribute to neuromuscular junction preservation during ALS progression.
    1. Neuroscience

    Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss

    Erin R Cullen, Mona Safari ... Matthew C Weston
    Epilepsy caused by focal Pten deletion is only prevented when both mTOR complexes are simultaneously inhibited, but not alone, suggesting they play independent roles in the development of epilepsy.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Neuroscience

    Heron: A Knowledge Graph editor for intuitive implementation of python based experimental pipelines

    George Dimitriadis, Ella Svahn ... Athena Akrami
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Ecology
    2. Plant Biology

    High-resolution kinetics of herbivore-induced plant volatile transfer reveal clocked response patterns in neighboring plants

    Jamie Mitchel Waterman, Tristan Michael Cofer ... Matthias Erb
    Real-time volatile emission kinetics reveal stress volatiles emitted from herbivore-damaged plants can sequentially prime and induce defense responses in undamaged plants following distinct temporal patterns.
    1. Developmental Biology
    2. Neuroscience

    Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

    Simon Desiderio, Frederick Schwaller ... Frederic Marmigere
    Combining mouse genetic, behavioral, and electrophysiological approaches revealed that a transcription factor is required to shape touch neurons' distal projections in the skin while dispensable for their survival and specification.
    1. Evolutionary Biology
    2. Medicine

    Taste shaped the use of botanical drugs

    Marco Leonti, Joanna Baker ... Julie Hawkins
    Plant drugs used by ancient Graeco-Roman societies have tastes and flavours that predict how they were used therapeutically.