A signal amplifier network that transmits mechanical pain is delineated through characterising an excitatory interneuron population in the spinal cord dorsal horn and defining the postsynaptic populations they regulate.
Elissavet Chartampila, Karim S Elayouby ... Helen E Scharfman
Supplementing the diet in early life with choline improved memory, neuronal morphology, and neuronal activity in mice with a genetic form of Alzheimer's disease, whereas low choline had mixed effects.
Identifying xanthohumol and its derivatives as PPARγ anatagonists provides new insight into how natural compounds beneficially treat obesity and metabolic syndrome, and provide new compounds for therapeutic development.
The distinct transcriptomic features of extraocular muscle satellite cells, partially mimicked by NaBu treatment, endow enhanced self-renewal and axon attraction, contribute to neuromuscular junction preservation during ALS progression.