25 results found
    1. Neuroscience

    Constructing an adult orofacial premotor atlas in Allen mouse CCF

    Jun Takatoh et al.
    A new three-step monosynaptic premotor tracing strategy in adult mice, together with registration to the Allen mouse common coordinate framework, uncovered precise spatial relationships of distinct orofacial premotor circuits in the brainstem.
    1. Ecology

    A small number of workers with specific personality traits perform tool use in ants

    István Maák et al.
    The likelihood to perform tool use during foraging is linked to personality traits in ants, suggesting an original interplay between consistent inter-individual variability and division of labor in social species.
    1. Neuroscience

    Visual attention modulates the integration of goal-relevant evidence and not value

    Pradyumna Sepulveda et al.
    Visual attention modulates the integration of the evidence that is most useful for achieving a goal in both perceptual and value-based decisions.
    1. Cell Biology
    2. Developmental Biology

    Zebrafish Posterior Lateral Line primordium migration requires interactions between a superficial sheath of motile cells and the skin

    Damian E Dalle Nogare et al.
    Epithelial cells utilize a covering sheath of motile cells to migrate in confinement.
    1. Cell Biology
    2. Computational and Systems Biology

    The transcriptomic response of cells to a drug combination is more than the sum of the responses to the monotherapies

    Jennifer EL Diaz et al.
    The transcriptomic profiles of the constituent monotherapies of synergistic drug pairs tend to be correlated and result in novel gene expression in the combinations.
    1. Computational and Systems Biology
    2. Neuroscience

    Tuning movement for sensing in an uncertain world

    Chen Chen et al.
    Animals work in a world full of surprises, where using energy to position sensors proportional to the location's expected information avoids the pitfalls of positioning them at the information maxima.
    1. Structural Biology and Molecular Biophysics

    Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms

    Katherine E Huffer et al.
    Structure-based alignment of TRP channels enables comparison of structural changes, ion permeation pathways and ligand-binding sites and reveals over-representation of structures that represent non-conducting states.
  1. Annual Report: 2019 in review

    We reflect on eLife’s efforts to transform research communication through improvements to science publishing, technology and research culture.
    1. Neuroscience

    Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains

    Jan Willem de Gee et al.
    Across species and domains of decision-making, pupil-linked phasic arousal predicts suppression biases in the accumulation of evidence leading up to a choice.
    1. Cancer Biology
    2. Computational and Systems Biology

    Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions

    Christopher J Lord et al.
    Computational approach to identify reproducible genetic interactions in cancer reveals that they are enriched among protein–protein interaction pairs.

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