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    1. Neuroscience

    Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1

    Robbert Havekes et al.
    The loss of neuronal connectivity in a brain region called the hippocampus significantly contributes to the cognitive impairments associated with sleep deprivation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    bMERB domains are bivalent Rab8 family effectors evolved by gene duplication

    Amrita Rai et al.
    A human three-helix Rab-binding domain can potentially bind to two Rab proteins simultaneously with different affinities at binding sites generated by gene duplication.
    1. Neuroscience

    Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains

    Jan Willem de Gee et al.
    Across species and domains of decision-making, pupil-linked phasic arousal predicts suppression biases in the accumulation of evidence leading up to a choice.
    1. Evolutionary Biology
    2. Neuroscience

    Mushroom body evolution demonstrates homology and divergence across Pancrustacea

    Nicholas James Strausfeld et al.
    Demonstrating extreme diversity across crustaceans while contrasting with evolutionary stability in insects, mushroom body homologues further underpin the unity of Pancrustacea and shed new light on arthropod brain evolution.
    1. Neuroscience

    Constructing an adult orofacial premotor atlas in Allen mouse CCF

    Jun Takatoh et al.
    A new three-step monosynaptic premotor tracing strategy in adult mice, together with registration to the Allen mouse common coordinate framework, uncovered precise spatial relationships of distinct orofacial premotor circuits in the brainstem.
    1. Structural Biology and Molecular Biophysics

    Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms

    Katherine E Huffer et al.
    Structure-based alignment of TRP channels enables comparison of structural changes, ion permeation pathways and ligand-binding sites and reveals over-representation of structures that represent non-conducting states.
    1. Computational and Systems Biology
    2. Developmental Biology

    An image-based data-driven analysis of cellular architecture in a developing tissue

    Jonas Hartmann et al.
    A computational strategy for extracting representative numerical features from 3D microscopy data enables in-depth quantitative analysis of cell and tissue organization through machine learning-driven data integration and context-guided visualization.
    1. Cell Biology
    2. Computational and Systems Biology

    Rewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitination

    Benjamin Groves et al.
    Two sets of modular components are sufficient to rewire MAPKs to regulate proteins through ubiquitination – a complementary pair of protein interaction domains and a phosphodegron.
  1. Annual Report: 2019 in review

    We reflect on eLife’s efforts to transform research communication through improvements to science publishing, technology and research culture.
    1. Cell Biology
    2. Developmental Biology

    Zebrafish Posterior Lateral Line primordium migration requires interactions between a superficial sheath of motile cells and the skin

    Damian E Dalle Nogare et al.
    Epithelial cells utilize a covering sheath of motile cells to migrate in confinement.