P4-ATPase BbCrpa detoxifies secondary metabolites via a unique vesicle-mediated transport pathway that targets the compounds into vacuoles.

The retromer complex serves as a bomb squad to retrieve and disarm the potentially harmful pool of Notch receptors in a timely manner and thereby safeguards against brain tumor formation.

An atomic model of the 3744-residue Tra1 protein reveals multiple transcription activator binding sites, its integration within the SAGA chromatin coactivator complex, and a striking similarity to DNA-repair factor DNA-PKcs.

Specific memories can be stored through changes in the postsynaptic cholinergic receptor composition at Drosophila mushroom body synapses.

Quantitative 3D lattice light sheet microscopy of unperturbed cells combined with electron tomography and acute loss of function experiments reveals how dynamic ESCRT-III/Vps4 assemblies succeed in reverse membrane budding on endosomes.

Telomere length is linked to DNA replication, and we found excessive telomeric origin firing caused by several distinct mutants did not lengthen telomeres, narrowing possible mechanisms.

Genetic and behavior analyses show that Caenorhabditis nematodes are lured to the predator Arthrobotrys oligospora by olfactory mimicry of food and sex cues.

Real-time visualization of Salmonella enterica and polarized macrophage interaction in the living host identifies an anti-inflammatory, pro-regenerative, and motionless macrophage subset as a survival niche during persistent infection.

Single mouse cytomegalovirus protein, m154, downmodulates surface expression of numerous targets important for NK and CD8 T cell activation by perturbing adaptor protein-1 sorting and redirecting targets to lysosomal degradation.

Chemical modifications near the tRNA anticodon and specific mRNA–tRNA pairs combine to control the ribosomal three-nucleotide mRNA reading frame, essential for the sequential addition of amino acids into polypeptide chains.