39 results found
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

    Mohd Anisul et al.
    Genetic integration of human protein abundance variation and COVID-19 susceptibility identifies proteins with potential causal roles in antiviral responses, coagulation, cytokine activation, and direct receptor interactions with SARS-CoV-2.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm

    Srijan Seal et al.
    An integrated empirical paradigm tracing immune strategies, underlying mechanisms and infection outcomes across reservoir host-pathogen systems, their specific ecological contexts, life-history features, and coevolutionary dynamics can reveal the actual patterns and processes underlying spillover in the wild.
    1. Epidemiology and Global Health

    FnCas9-based CRISPR diagnostic for rapid and accurate detection of major SARS-CoV-2 variants on a paper strip

    Manoj Kumar et al.
    A newly developed lateral flow assay can diagnose mutational signatures of major SARS CoV-2 variants in a rapid, inexpensive, and sequence-free manner.
    1. Microbiology and Infectious Disease

    Respiratory and intestinal epithelial cells exhibit differential susceptibility and innate immune responses to contemporary EV-D68 isolates

    Megan Culler Freeman et al.
    Parallel studies in primary human airway cells and stem cell-derived enteroids show that Enterovirus D-68 differentially infects and induces innate immune signaling in the respiratory and intestinal epithelium.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses

    Dylan H Morris et al.
    Viruses, including SARS-CoV-2, retain infectivity longer at low temperatures and extreme relative humidities because these conditions slow down the chemical reactions that inactivate those viruses.
    1. Epidemiology and Global Health

    Lives saved with vaccination for 10 pathogens across 112 countries in a pre-COVID-19 world

    Jaspreet Toor et al.
    Vaccination activities that occurred before the COVID-19 pandemic, 2000-2019, are estimated to avert 50 million deaths, highlighting the enormous benefits of continued and improving vaccination.
    1. Microbiology and Infectious Disease

    Smartphone screen testing, a novel pre-diagnostic method to identify SARS-CoV-2 infectious individuals

    Rodrigo M Young et al.
    PCR testing for SARS-CoV-2 from samples taken from smartphone screens, Phone Screen Testing, provides a sensitive, cost-effective, simple, and non-invasive new method that could boost COVID-19 mass test screening.
    1. Epidemiology and Global Health

    Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection

    Allison Koenecke et al.
    Patients exposed to ⍺1-AR antagonists have reduced risks of mechanical ventilation and death in lower respiratory tract infection-related illnesses, highlighting the need for prospective trials assessing ⍺1-AR antagonists' effectiveness in COVID-19.
    1. Medicine

    Sensitivity of ID NOW and RT–PCR for detection of SARS-CoV-2 in an ambulatory population

    Yuan-Po Tu et al.
    Although the ID NOW platform is less sensitive than RT–PCR for identification of SARS-CoV-2 infection, it provides high positive and negative predictive values in low-prevalence populations.
    1. Immunology and Inflammation
    2. Medicine

    Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death

    Jack Gisby et al.
    Severe COVID-19 is characterised by a plasma proteomic biomarker signature, indicating innate immune activation, leucocyte–endothelial interactions, and epithelial injury.

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