804 results found
    1. Genetics and Genomics

    Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues

    Mingqi Zhou, Ian Tamburini ... Marcus M Seldin
    A population resource to investigate mechanisms of organ communication.
    1. Cancer Biology
    2. Evolutionary Biology

    High-density sampling reveals volume growth in human tumours

    Arman Angaji, Michel Owusu ... Johannes Berg
    Spatial genomics reveals the mode of evolution of a tumour based on the positions of mutations in high-resolution samples.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

    Yong H Woo, Hifzur Ansari ... Arnab Pain
    Analysis of chromerid algal genomes reveals how apicomplexans have evolved from free-living algae into successful eukaryotic parasites via massive losses and re-inventing functional roles of genes.
    1. Immunology and Inflammation
    2. Medicine

    Transcriptome network analysis implicates CX3CR1-positive type 3 dendritic cells in non-infectious uveitis

    Sanne Hiddingh, Aridaman Pandit ... Jonas JW Kuiper
    CX3CR1-positive dendritic cells are altered in patients with non-infectious uveitis.
    1. Developmental Biology

    A gene regulatory network for neural induction

    Katherine E Trevers, Hui-Chun Lu ... Claudio D Stern
    A comprehensive resource based on analysis of the responses of embryonic ectoderm cells to signals from the 'organizer' (the node) including transcriptional responses and epigenetic changes with fine temporal dynamics, predicted regulatory interactions, and conservation among vertebrates.
    1. Neuroscience

    Dopamine signaling regulates predator-driven changes in Caenorhabditis elegans’ egg laying behavior

    Amy Pribadi, Michael A Rieger ... Sreekanth H Chalasani
    Caenorhabditis elegans responds to predator threat by using dopamine signaling to alter the distribution of their eggs.
    1. Neuroscience

    Cerebellar involvement in an evidence-accumulation decision-making task

    Ben Deverett, Sue Ann Koay ... Samuel S-H Wang
    In a new evidence-accumulation decision-making task, activity of the lateral posterior cerebellum is necessary for accurate performance, and somatic and dendritic activity in Purkinje cells contains choice/evidence and error-related information.
    1. Neuroscience

    A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments

    Gabriel Loewinger, Erjia Cui ... Francisco Pereira
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Decreased brain connectivity in smoking contrasts with increased connectivity in drinking

    Wei Cheng, Edmund T Rolls ... Jianfeng Feng
    The findings have a major impact in understanding the different reward systems involved in two types of addictive behavior, and these advances have implications for prevention and treatment.
    1. Neuroscience

    Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality

    Brian Kim, Seth Haney ... Mark A Stopfer
    The odor-elicited responses of olfactory receptor neurons consist of a discrete set of four spike pattern motifs, each with distinct adaptation properties, together amplifying distinctions between similar and temporally complex chemical inputs such as odor plumes.

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