7,106 results found
    1. Genetics and Genomics
    2. Medicine

    Differences in pathways contributing to thyroid hormone effects on postnatal cartilage calcification versus secondary ossification center development

    Gustavo A Gomez, Patrick Aghajanian ... Subburaman Mohan
    Mouse molecular genetics and in vivo functional studies reveal that thyroid hormone is necessary for punctual proximal femur head development by a mechanism that differs temporally and molecularly from the secondary ossification center at the distal femur.
    1. Cell Biology
    2. Genetics and Genomics

    Circadian oscillations in Trichoderma atroviride and the role of core clock components in secondary metabolism, development, and mycoparasitism against the phytopathogen Botrytis cinerea

    Marlene Henríquez-Urrutia, Rebecca Spanner ... Luis F Larrondo
    The biocontrol fungus Trichoderma atroviride possess a functional circadian clock, whose components impact the production of secondary metabolites and also play a role in the interaction with fungi such as the phytopathogen Botrytis cinerea.
    1. Cell Biology
    2. Developmental Biology

    Decoding the IGF1 signaling gene regulatory network behind alveologenesis from a mouse model of bronchopulmonary dysplasia

    Feng Gao, Changgong Li ... Parviz Minoo
    Publicly available gene expression data and proven methodologies for building model Gene Regulatory Networks are applied to successfully construct the IGF1 signaling GRN behind alveologenesis, serving as a pioneer in transforming how lung development and its associated diseases is approached.
    1. Biochemistry and Chemical Biology
    2. Ecology

    Secondary metabolites of Hülle cells mediate protection of fungal reproductive and overwintering structures against fungivorous animals

    Li Liu, Christoph Sasse ... Gerhard H Braus
    Xanthones produced by the filamentous fungus Aspergillus nidulans protect its sexual structures from predation by arthropods.
    1. Ecology
    2. Plant Biology

    The decoration of specialized metabolites influences stylar development

    Jiancai Li, Meredith C Schuman ... Ian T Baldwin
    Regulation of diterpene glycoside malonylation status influences stylar elongation through affecting auxin signaling in Nicotiana attenuata.
    1. Biochemistry and Chemical Biology
    2. Ecology

    Fungi: Sex and self defense

    Milton T Drott
    The fungus Aspergillus nidulans produces secondary metabolites during sexual development to protect itself from predators.
    Version of Record
    Insight
    1. Developmental Biology
    2. Evolutionary Biology

    Secondary ossification center induces and protects growth plate structure

    Meng Xie, Pavel Gol'din ... Andrei S Chagin
    The principle underlying the appearance of the growth plate, an organ responsible for longitudinal growth, has implications for various cartilage pathologies including growth abnormalities in children, trauma and osteoarthritis.
    1. Developmental Biology

    A mammalian Wnt5a–Ror2–Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis

    Kuan Zhang, Erica Yao ... Pao-Tien Chuang
    Regulation of cellular properties such as ligand secretion and migratory ability through changes in the cytoskeleton mediated by a Wnt5a–Ror2–Vangl2 axis is a major determinant of alveolar formation.
    1. Developmental Biology

    Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria

    Kuan Zhang, Erica Yao ... Pao-Tien Chuang
    Mitochondrial activity and distribution control alveolar formation by conferring distinct cellular properties.
    1. Developmental Biology
    2. Neuroscience

    Role of Nrp1 in controlling cortical inter-hemispheric circuits

    Fernando Martín-Fernández, Ana Bermejo-Santos ... Marta Nieto
    Transient expression of Nrp1 is required in postnatal stages for terminal arborization and innervation of secondary areas during the development of somatosensory callosal circuits.

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