1,789 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Global biogeographic sampling of bacterial secondary metabolism

    Zachary Charlop-Powers et al.
    Pyro-sequencing of two genes involved in bacterial secondary metabolism provides new insights into the rich reservoir of biologically active small molecules found in environmental bacteria.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Novel mechanism of metabolic co-regulation coordinates the biosynthesis of secondary metabolites in Pseudomonas protegens

    Qing Yan et al.
    The production of two secondary metabolites is co-regulated in a bacterium via an intermediate in one pathway that is converted into signals to activate the second pathway.
    1. Microbiology and Infectious Disease

    Chromatin mapping identifies BasR, a key regulator of bacteria-triggered production of fungal secondary metabolites

    Juliane Fischer et al.
    Genome-wide chromatin mapping during bacterial-fungal cocultivation identifies the Myb-like transcription factor BasR as the major regulatory node of bacteria-triggered production of fungal secondary metabolites.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals

    Markus Gressler et al.
    Elevated methionine levels, or a shortage of nitrogen or iron, induce terrein production in the fungus Aspergillus terreus.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster

    Hyun Bong Park et al.
    A new type of hybrid nonribosomal peptide synthetase (NRPS)-like-pteridine synthase biosynthetic pathway has been illuminated via genome mining.
    1. Ecology
    2. Microbiology and Infectious Disease

    Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin

    Maria Cristina Stroe et al.
    A silent gene cluster of the fungus Aspergillus fumigatus is activated by a bacterium and leads to the production of a novel spore germination inhibitor targeting the inducing bacterium.
    1. Ecology
    2. Plant Biology

    The decoration of specialized metabolites influences stylar development

    Jiancai Li et al.
    Regulation of diterpene glycoside malonylation status influences stylar elongation through affecting auxin signaling in Nicotiana attenuata.
    1. Neuroscience

    Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy

    Sandra Kleinecke et al.
    Dysfunctions of myelin peroxisomes cause a lysosomal storage-like disorder associated with alterations in glial and axonal membranes, which is the likely cause of nerve impairment in peroxisomal disorders.
    1. Cell Biology

    SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

    Ashutosh Kumar et al.
    LRRC8A is an essential component of a mechanoresponsive ion channel signaling complex that tunes skeletal muscle differentiation, muscle cell size, function and metabolic pathways to regulate adiposity and systemic glycemia.
    1. Developmental Biology

    Fatty acid β-oxidation is required for the differentiation of larval hematopoietic progenitors in Drosophila

    Satish Kumar Tiwari et al.
    Genetic and molecular analyses reveal the decisive role of fatty acid oxidation (FAO) acting downstream to the ROS-JNK circuit essential for hemocyte progenitor differentiation in Drosophila..

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