Predicting multivariate phenotypic evolution.

Cell biological features are subject to stochastic forces of mutation and random genetic drift, which together cause lineages exposed to identical selection pressures to diverge, and mean phenotypes to deviate from expectations under optimizing selection.

Newly formed tetraploid cells rapidly lose extra centrosomes acquired upon tetraploidization via asymmetric centrosome clustering during cell division and selective advantage of tetraploid daughter cells that inherit a single centrosome.

A simple fluorescent dye method allows visualization of whiskers, facilitating studies of rodent tactile behavior.

Integrative modeling of results from chemical cross-linking, electron microscopy, and homology modeling yield a three-dimensional model of the entire Mediator complex in yeast.

Mesoscale cortical calcium activity correlating with single cortical and thalamic cell spiking reveal rich dynamics and support a novel approach for investigating in vivo functional networks in the mammalian brain.

A novel single-objective light-sheet microscope with unparalleled spatiotemporal resolution enables imaging and optical manipulation of diverse biological specimens and processes.

Selection acting on SARS-CoV-2 variants altering the infectivity profile depends on levels of transmission in the community, and this dependence is used to infer Alpha and Delta variants infectivity profiles.

There are inherent tradeoffs in the control of cellular response variability by paracrine communication during the establishment of initial wound response signaling gradients.

The present fluorescence polarization microscopy method enables the determination of the spatial orientations and lifetimes of a transporter protein in individual conformational states required for understanding the complex conformational mechanism underlying its function, applicable to investigation of other membrane proteins.