4,044 results found
    1. Neuroscience

    A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

    Brad K Hulse, Hannah Haberkern ... Vivek Jayaraman
    An analysis of the first complete synaptic resolution connectome of Drosophila's navigation circuit uncovers neural network motifs supporting broadly relevant sensorimotor computations.
    1. Neuroscience

    Transforming descending input into behavior: The organization of premotor circuits in the Drosophila Male Adult Nerve Cord connectome

    Han SJ Cheong, Katharina Eichler ... Gwyneth M Card
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Allosteric conformational ensembles have unlimited capacity for integrating information

    John W Biddle, Rosa Martinez-Corral ... Jeremy Gunawardena
    The effective higher-order binding cooperativities arising from an ensemble of dynamically interchanging conformations are identified and shown to fully describe integration of binding information at thermodynamic equilibrium.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Asynchrony between virus diversity and antibody selection limits influenza virus evolution

    Dylan H Morris, Velislava N Petrova ... Colin A Russell
    Despite the virus' error prone polymerase, influenza virus antigenic evolution is rare, even in previously immune hosts, virus replication occurs before producing new antibodies.
    1. Neuroscience

    Morphology and ultrastructure of external sense organs of Drosophila larvae

    Vincent Richter, Anna Rist ... Andreas S. Thum
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX

    Aivaras Vaškevičius, Denis Baronas ... Daumantas Matulis
    A series of compounds were synthesized and demonstrated to form a specific covalent bond with His64 of CAIX, an anticancer target, a strategy applicable to any drug design project.
    1. Computational and Systems Biology
    2. Neuroscience

    A connectome and analysis of the adult Drosophila central brain

    Louis K Scheffer, C Shan Xu ... Stephen M Plaza
    New reconstruction methods are used to create a publicly available dense reconstruction of the neurons and chemical synapses of central brain of Drosophila, with analysis of its graph properties.
    1. Developmental Biology
    2. Neuroscience

    Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

    Subhash Kulkarni, Monalee Saha ... Pankaj Jay Pasricha
    Mesoderm-derived enteric neurons born in the post-natal vertebrates drive maturation and aging of the enteric nervous system.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability

    Anil Kumar Vijjamarri, Xiao Niu ... Alan G Hinnebusch
    The yeast mRNA decapping enzyme Dcp1/Dcp2 repressses many genes whose products are required on poor carbon or nitrogen sources in nutrient-replete cells by mRNA decapping and degradation or translational repression, adding post-transcriptional controls to the transcriptional repression of these functions.
    1. Cell Biology
    2. Computational and Systems Biology

    From actin waves to mechanism and back: How theory aids biological understanding

    Carsten Beta, Leah Edelstein-Keshet ... Arik Yochelis
    Mathematical methods reveal common underlying principles in diverse models of intracellular actin waves.

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