Goblet cells secrete mucins—which are key components of mucus—in a process that is regulated by calcium ions, which enter the goblet cells via a mechanism involving a channel protein called TRPM5.

Capsular polysaccharides of Acinetobacter baumannii regulate type VI secretion system activity, balancing self-protection with interbacterial competitiveness.

A CRISPR-based genomic screen identifies the ER cargo receptor SURF4 as a key determinant in the secretion of PCSK9, a protein that regulates human cholesterol levels and cardiovascular disease risk.

Proteins for bacterial flagella biogenesis contain two discrete export signals, recognised sequentially by the flagellar Type III Secretion System to facilitate initial docking and subsequent opening of the export gate.

A novel multi-hormones secreting chromaffin-like cell type was identified using single-cell RNA sequencing, suggesting the molecular mechanism of ectopic ACTH and CRH pheochromocytoma associated with Cushing’s syndrome.

Single-cell RNA sequencing provides a detailed understanding of the cues controlling in vitro differentiation of human B cells into antibody-secreting cells (ASCs), uncovering a novel pre-ASC population present ex vivo in lymphoid tissues that progress through a germinal center-like state.

Drosophila HNF4 directs a developmental switch at the onset of adulthood that suppresses diabetes by promoting mitochondrial function and supporting glucose-stimulated insulin secretion.

Reconstitution of interleukin-1β secretion in non-macrophage cells implicates how this pro-inflammatory cytokine enters into the unconventional pathway of secretion through autophagy.

AatD is a novel acyltransferase that mediates N-palmitoylation of glycine, a process not previously described, that results in the secretion of lipoproteins to the bacterial cell surface.

A novel component of type III protein secretion systems involved in the assembly of the secretion machine is reported.