6,679 results found
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structure of the Helicobacter pylori Cag type IV secretion system

    Jeong Min Chung et al.
    The Helicobacter pylori Cag T4SS has unique structural features, including unexpected symmetry mismatch between sub-complexes, with implications for protein secretion.
    1. Microbiology and Infectious Disease

    A protein secreted by the Salmonella type III secretion system controls needle filament assembly

    Junya Kato et al.
    A novel component of type III protein secretion systems involved in the assembly of the secretion machine is reported.
    1. Cell Biology
    2. Human Biology and Medicine

    Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion

    Caroline Lekszas et al.
    The first human TANGO1-associated syndromal disease manifests as impaired collagen secretion, highlighting the importance of TANGO1 in human pathophysiology.
    1. Structural Biology and Molecular Biophysics

    The structure of the endogenous ESX-3 secretion system

    Nicole Poweleit et al.
    The structure of the endogenous ESX-3 secretion system reveals a highly coordinated inner membrane complex and suggests a mechanism for the regulated secretion of ESX substrates.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults

    William E Barry, Carl S Thummel
    Drosophila HNF4 directs a developmental switch at the onset of adulthood that suppresses diabetes by promoting mitochondrial function and supporting glucose-stimulated insulin secretion.
    1. Microbiology and Infectious Disease

    Visualization of the type III secretion mediated Salmonella–host cell interface using cryo-electron tomography

    Donghyun Park et al.
    Visualization of the type III secretion mediated Salmonella-host cell interface reveals the intact translocon and the profound remodeling of the host membrane at unprecedented resolution.
    1. Microbiology and Infectious Disease

    Mechanisms of substrate recognition by a typhoid toxin secretion-associated muramidase

    Tobias Geiger et al.
    Biochemical analyses and the crystal structure of TtsA reveal fundamental insight into the mechanisms by which this muramidase recognizes its peptidoglycan substrate to facilitate typhoid toxin secretion.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle

    Qingnian Goh et al.
    Fusion of muscle progenitors drives continuous myonuclear accretion during exercise and impacts various adaptations in skeletal muscle including response to injury and hypertrophy.
    1. Cell Biology

    ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion

    Amy J Curwin et al.
    The release of Acb1 protein from yeast cells requires the ESCRT-III complex to stabilize the compartment for unconventional protein secretion (CUPS).
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

    Min Zhang et al.
    Reconstitution of interleukin-1β secretion in non-macrophage cells implicates how this pro-inflammatory cytokine enters into the unconventional pathway of secretion through autophagy.

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