8,671 results found
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults

    William E Barry, Carl S Thummel
    Drosophila HNF4 directs a developmental switch at the onset of adulthood that suppresses diabetes by promoting mitochondrial function and supporting glucose-stimulated insulin secretion.
    1. Cell Biology

    The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9

    Brian T Emmer et al.
    A CRISPR-based genomic screen identifies the ER cargo receptor SURF4 as a key determinant in the secretion of PCSK9, a protein that regulates human cholesterol levels and cardiovascular disease risk.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structure of the Helicobacter pylori Cag type IV secretion system

    Jeong Min Chung et al.
    The Helicobacter pylori Cag T4SS has unique structural features, including unexpected symmetry mismatch between sub-complexes, with implications for protein secretion.
    1. Cell Biology

    ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion

    Amy J Curwin et al.
    The release of Acb1 protein from yeast cells requires the ESCRT-III complex to stabilize the compartment for unconventional protein secretion (CUPS).
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

    Min Zhang et al.
    Reconstitution of interleukin-1β secretion in non-macrophage cells implicates how this pro-inflammatory cytokine enters into the unconventional pathway of secretion through autophagy.
    1. Cell Biology
    2. Neuroscience

    Reconstruction of genetically identified neurons imaged by serial-section electron microscopy

    Maximilian Joesch et al.
    A new pipeline of electron microscopy techniques reduces the time required to visualize genetically targeted neurons and their connections by two orders of magnitude.
    1. Microbiology and Infectious Disease

    A protein secreted by the Salmonella type III secretion system controls needle filament assembly

    Junya Kato et al.
    A novel component of type III protein secretion systems involved in the assembly of the secretion machine is reported.
    1. Structural Biology and Molecular Biophysics

    The structure of the endogenous ESX-3 secretion system

    Nicole Poweleit et al.
    The structure of the endogenous ESX-3 secretion system reveals a highly coordinated inner membrane complex and suggests a mechanism for the regulated secretion of ESX substrates.
    1. Cell Biology

    Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion

    Caroline Lekszas et al.
    The first human TANGO1-associated syndromal disease manifests as impaired collagen secretion, highlighting the importance of TANGO1 in human pathophysiology.
    1. Cell Biology
    2. Computational and Systems Biology

    Highly localized intracellular Ca2+ signals promote optimal salivary gland fluid secretion

    Takahiro Takano et al.
    Measurement of physiological intracellular Ca2+ signals following neural stimulation in vivo reveals distinct spatiotemporal characteristics that promote optimal salivary gland fluid secretion.

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