Chromosomal instability induced in solid tumors can combine with macrophages that are made highly phagocytic to thereby initiate elimination of and immunity against poorly immunogenic tumors in immunocompetent mice.
A novel role of the mitochondrial BKCa channel involves the metabolic reprogramming of breast cancer cells, facilitating their unrestricted proliferation and O2-independence, which is also of potential clinical relevance.
Diego Balboa, Jonna Saarimäki-Vire ... Timo Otonkoski
Mutations causing proinsulin misfolding trigger unfolded protein response and lead to impaired proliferation and reduced mTORC1 signalling of developing beta-cells in a patient-derived induced pluripotent stem cell disease model.
The endosomal apparatus of African trypanosomes consists a continuous membrane system with functional subdomains rather than distinct compartments for early, late, and recycling endosomes.
Live-cell imaging and biochemical studies reveal that bradyzoites exhibit reduced Ca2+ stores, dampened calcium responses, and reduced energy levels consistent with their quiescent sate, but that they rapidly respond to environmental conditions to emerge from dormancy.
Brian T Emmer, Geoffrey G Hesketh ... David Ginsburg
A CRISPR-based genomic screen identifies the ER cargo receptor SURF4 as a key determinant in the secretion of PCSK9, a protein that regulates human cholesterol levels and cardiovascular disease risk.
A biochemical approach shows that SOX4 guaranteed the PGR protein stability through repressing the ubiquitin E3 ligase HERC4, to make the stroma cell conducive for response to progesterone and decidualization.
Tamara Garrido-Gomez, Nerea Castillo-Marco ... Carlos Simon
The in vivo transcriptomic fingerprint encoding defective decidualization comprises 120 genes associated with an imbalance hormonal signaling in the decidual endometria of women who developed severe preeclampsia.
