252 results found
    1. Cell Biology
    2. Neuroscience

    Golgi-independent secretory trafficking through recycling endosomes in neuronal dendrites and spines

    Aaron B Bowen et al.
    Neurons use a non-canonical secretory network to deliver select proteins to postsynaptic sites in dendrites.
    1. Cell Biology
    2. Neuroscience

    Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa

    Fushun Fan et al.
    Analyses of knockout mice and a biochemical screen of interacting proteins reveal that exophilin-8 forms a large network of protein interactions to efficiently retain secretory granules beneath the plasma membrane for exocytosis.
    1. Human Biology and Medicine

    Stem Cells: What silent mutations say about the human airways

    Matthew L Donne, Jason R Rock
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

    Paolo Grumati et al.
    Full length RTN3 homodimerization mediates ER tubules fragmentation and their subsequent delivery to lysosome.
    1. Developmental Biology

    SOX2 regulates acinar cell development in the salivary gland

    Elaine Emmerson et al.
    Establishment of the acinar lineage in the salivary gland requires SOX2 and parasympathetic nerves.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Efficient protein targeting to the inner nuclear membrane requires Atlastin-dependent maintenance of ER topology

    Sumit Pawar et al.
    Efficient targeting of membrane proteins from the endoplasmic reticulum (ER) to the inner nuclear membrane depends on GTP hydrolysis by Atlastin GTPases and their function in maintaining an interconnected topology of the ER network.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking

    Pornchai Kaewsapsak et al.
    Live-cell nanometer-resolution RNA labeling method enables transcriptome-wide mapping of endogenous RNAs in nuclear, cytosol, ER, and mitochondrial subcompartments.
    1. Cell Biology

    Sec24 phosphorylation regulates autophagosome abundance during nutrient deprivation

    Saralin Davis et al.
    Phosphorylation of a core trafficking component, the COPII coat subunit Sec24, regulates cross-talk between the secretory and autophagy machinery during starvation.
    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

    Simon Mysling et al.
    Building on previous work (Mysling et al., 2016), it is shown that angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase activity by catalyzing the unfolding of its hydrolase domain.

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