Natural variation for an adaptively important life history trait is largely due to variation at a single, major-effect locus with multiple alleles, demonstrating that not all complex traits are massively polygenic.
Plasmodium falciparum invasion protein EBA-175, once shed from the parasite surface post invasion, facilitates RBC clustering and enhances parasite growth while simultaneously enabling parasite immune evasion of host neutralizing antibodies.
Stem cell derived ventral-spinal cord excitatory neurons self-assemble into a rhythmically bursting neural network whose speed and intercellular coordination are both instructively modulated by cell-type specific interactions with inhibitory neurons.
Increased mass enhances speed but compromises turning capacity in pursuit predators; this has widespread ramifications for the best strategies for predators and prey during chases according to their relative masses.
The combination of statistical inference and perturbation experiments reveals that trans-generational inheritance of cell size and cell-cycle speed, coupled through a minimum-size checkpoint, shapes paradoxical cell-cycle correlations in lineage trees.
Super-resolution STED microscopy is demonstrated for the first time in the deeply embedded mouse hippocampus in vivo, revealing direct evidence for an unprecedentedly high level of synapse remodeling in a brain structure closely associated with memory processing.