53 results found
    1. Genomics and Evolutionary Biology

    A large gene family in fission yeast encodes spore killers that subvert Mendel’s law

    Wen Hu et al.
    Two members of a large fission yeast (Schizosaccharomyces pombe) gene family are shown to act as spore killers that enhance their own transmission into progenies by impeding the maturation of spores not inheriting them.
    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    Heredity: The gene family that cheats Mendel

    J Dylan Shropshire, Antonis Rokas
    Some alleles of the wtf gene family can increase their chances of spreading by using poisons to kill other alleles, and antidotes to save themselves.
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    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    The Natural History of Model Organisms: Insights into mammalian biology from the wild house mouse Mus musculus

    Megan Phifer-Rixey, Michael W Nachman
    Studies of the house mouse Mus musculus have provided important insights into mammalian biology, and efforts to study wild house mice and to create new inbred strains from wild populations have the potential to increase its usefulness as a model system.
    1. Neuroscience

    Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function

    Bo Zhao et al.
    Super-resolution microscopy reveals a highly organized compartment in the stereocilia of mechanosensory hair cells of the inner ear, which is critical for hair cell function and affected in disease.
    1. Biophysics and Structural Biology
    2. Cell Biology

    Mechanical design principles of a mitotic spindle

    Jonathan J Ward et al.
    Precise control of microtubule architecture greatly increases the force that the spindle can exert on chromosomes.
    1. Biophysics and Structural Biology
    2. Cell Biology

    A high-resolution morphological and ultrastructural map of anterior sensory cilia and glia in Caenorhabditis elegans

    David B Doroquez et al.
    The three-dimensional structures of 50 sensory cilia present in the head of the adult C. elegans hermaphrodite have been reconstructed to provide a foundation for investigations into the mechanisms by which the diversity of cilia structures is generated and how this structural diversity is related to specific sensory neuron functions.
    1. Cell Biology
    2. Genes and Chromosomes

    Imaging the fate of histone Cse4 reveals de novo replacement in S phase and subsequent stable residence at centromeres

    Jan Wisniewski et al.
    Internally tagged, functional Cse4/CENP-A/CenH3 histone variant is exclusively centromeric and stable through the budding yeast cell cycle after replacement in S phase.
    1. Neuroscience

    Odor-identity dependent motor programs underlie behavioral responses to odors

    Seung-Hye Jung et al.
    Flies respond to odors by modulating multiple independently modulated motor programs.
    1. Biophysics and Structural Biology
    2. Genes and Chromosomes

    Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction

    Gurunathan Laxmikanthan et al.
    The structure of a multi-protein DNA recombination reaction intermediate reveals how regulation is achieved by protein-mediated DNA wrapping around a core enzyme-substrate complex.

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