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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Statistical modeling based on structured surveys of Australian native possum excreta harboring Mycobacterium ulcerans predicts Buruli ulcer occurrence in humans

    Koen Vandelannoote, Andrew H Buultjens ... Timothy P Stinear
    The systematic field testing of excreta from Australian native possums for the bacterial pathogen Mycobacterium ulcerans can be used to build statistical models that predict the regions in southeast Australia where humans will subsequently get Buruli ulcer.
    1. Cancer Biology
    2. Computational and Systems Biology

    Defining the biological basis of radiomic phenotypes in lung cancer

    Patrick Grossmann, Olya Stringfield ... Hugo JWL Aerts
    Radiomics allows automated quantification of the radiographic phenotype of a tumor across diverse patient cohorts and is connected to the underlying molecular pathway activities, which together determine the clinical outcome.
    1. Neuroscience

    Quantitative neuroanatomy for connectomics in Drosophila

    Casey M Schneider-Mizell, Stephan Gerhard ... Albert Cardona
    A new method that uses the cellular neuroanatomy of neuronal connectivity to quickly and robustly reconstruct neuronal circuits in Drosophila from large electron microscopy volumes.
    1. Epidemiology and Global Health

    Coverage and system efficiencies of insecticide-treated nets in Africa from 2000 to 2017

    Samir Bhatt, Daniel J Weiss ... Peter W Gething
    Insecticide-treated net requirements for Africa have been underestimated, but mitigating for inefficiencies in net distributions can produce a cost effective path to universal coverage.
    1. Computational and Systems Biology
    2. Ecology

    Spatial structure favors microbial coexistence except when slower mediator diffusion weakens interactions

    Alexander Lobanov, Samantha Dyckman ... Babak Momeni
    Investigating microbial communities in a spatial environment in silico suggests that spatial structure promotes higher coexistence by allowing spatial self-organization, but can hinder coexistence by weakening interactions mediated through diffusible metabolites.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Systems level identification of a matrisome-associated macrophage polarisation state in multi-organ fibrosis

    John F Ouyang, Kunal Mishra ... Jacques Behmoaras
    A meta-analysis of single-cell data reveals an advanced and conserved polarisation state of SPP1+ macrophages in multiple human fibrotic tissues.
    1. Neuroscience

    An electrophysiological marker of arousal level in humans

    Janna D Lendner, Randolph F Helfrich ... Robert T Knight
    Non-oscillatory brain activity can be used to monitor arousal levels during both NREM and REM sleep as well as under general anesthesia with propofol.
    1. Cancer Biology
    2. Genetics and Genomics

    Single-cell multiomics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

    Rebecca Warfvinge, Linda Geironson Ulfsson ... Göran Karlsson
    Single-cell analysis of CML patients bone marrow at diagnosis reveals coexistence of CD26-CD35+ healthy stem cells and CD26+CD35- CML stem cells, and how the ratio between these impacts TKI response.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation

    Anthony J Linares, Chia-Ho Lin ... Douglas L Black
    The RNA binding protein PTBP1 controls an extensive program of alternative splicing in embryonic stem cells, one function of which is to repress neuronal transcriptional programs.
    1. Developmental Biology

    A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes

    Michelle A Carmell, Gregoriy A Dokshin ... David C Page
    GCNA proteins comprise a previously unnoticed family of proteins that has been enriched in cells carrying a heritable genome since the invention of sexual reproduction in eukaryotes, and has had reproductive function for at least 600 million years.